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CTS™ Immune Cell SR X

CTS™ Immune Cell Serum Replacement (SR) is designed to support expansion of in vitro cultured human immune cells such as T cells when added to a basal cell culture media such as CTS™ OpTmizer™ T cell Expansion SFM or CTS™ AIM-V™ SFM. CTS™ Immune Cell SR is a defined xeno-free formulation and does not contain bovine or other non-human, animal-derived components.

• Minimizes the supply and safety risks associated with human serum
• Supports expansion of polyclonal T cells (CD3/CD28 bead-activated, OKT3 mAb-activated, virus-specific and tumor-specific T cells)
• Supports T cell phenotype (CD4, CD8, and CD62L) similar to human serum
• Supports expansion of gene-modified CAR T cells (lentiviral transduction)
• Reduces the cost and time associated with qualifying human serum
• Generic enough to use with the base media of your choice

Security of supply and safety
CTS™ Immune Cell SR is a defined xeno-free formulation that contains no bovine or other non-human, animal-derived components at the primary component level. The site is FDA registered and has an ISO13485-certified quality management system. The methods and controls used for the manufacturing are in conformity with current Good Manufacturing Practices for medical devices, 21 CFR Part 820, of the regulation. Full traceability documentation such as Certificate of Origin, Certificate of Analysis, and Drug Master File are available. The product can be scaled to meet future clinical and commercial demand. Alternate manufacturing sites are available as further risk mitigation.

T cell qualified
CTS™ Immune Cell SR can replace human serum at similar concentrations and achieve similar performance. CTS™ Immune Cell SR supports expansion of polyclonal T cells (CD3/CD28 bead-activated and TILs), T Cell phenotypes (CD4, CD8 and CD62L), and expansion of gene-modified CAR T cells (lentiviral transduction). Every lot is pre-qualified in a functional T cell assay using CTS™ Dynabeads™ CD3/CD28-activated primary T cells to ensure consistent performance. This reduces the cost and time associated with human serum lot testing.

Versatility
CTS™ Immune Cell SR can replace human serum at similar concentrations without sacrificing performance in several different base media such as CTS™ OpTmizer™ T Cell Expansion SFM and CTS™ AIM-V™ SFM or other commercial media designed for immune cells. Varying dilutions of CTS™ Immune Cell SR should be tested to determine the optimal concentration needed for your cell type and basal media.

What you get
CTS™ Immune Cell SR is available in a 50 mL bottle for small volume users as well as a 500 mL bottle for larger volume users. For added convenience, the product can be freeze-thawed once if smaller aliquots are needed. CTS™ Immune Cell SR can be added to your standard base media at similar concentrations as human serum.

$2,305.75 Add to cart View Product Details

CTS™ OpTmizer™ T-Cell Expansion SFM, no phenol red, bottle format, 1000mL

Gibco CTS OpTmizer T-Cell Expansion SFM supports the growth and expansion of human T lymphocytes. It is a complete serum-free, xeno-free medium consisting of CTS OpTmizer T-Cell Expansion Basal Medium and CTS OpTmizer T-Cell Expansion Supplement, which are mixed together prior to use.

CTS OpTmizer T-Cell Expansion SFM is available with and without phenol red. This version of CTS OpTmizer SFM lacks phenol red, and is available in both bottle and bag format.

Features of CTS OpTmizer T-Cell Expansion SFM include:
• Supports high-density T cell culture (>4 x 10⁶ CD3+ T-cells/mL)
• Supports T-cell activation using Dynabeads magnetic beads, soluble antibodies, and stimulatory antibody-presenting cell protocols
• Similar phenotype, function (e.g., cytokine secretion profile), and viability to T-cells cultured with conventional human AB serum-supplemented medium
• Supports a T-cell phenotype similar to human serum-supplemented medium
• Demonstrates enhanced efficacy and persistence of CART-19 cells when grown in medium supplemented with CTS Immune Cell Serum Replacement (ICSR)

Demonstrated functional performance
Cells grown in CTS OpTmizer T-Cell Expansion SFM with or without human serum demonstrate good cytokine production profiles in polyclonally activated T cells. CTS OpTmizer T-Cell Expansion SFM maintains the desired the CD62L+ central memory T-cell phenotype.

CTS™ Immune Cell SR X

CTS™ OpTmizer™ T-Cell Expansion SFM, no phenol red, bottle format, 1000mL

Cucurbitacin E

Culture Tube Cap for 13mm Tubes, Blue

Culture Tube Cap for 13mm Tubes, Clear

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Culture Tube Cap for 16mm Tubes , Blue

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Culture Tube Cap for 18mm Tubes, Blue

Culture Tube Cap for 18mm Tubes, Clear

Culture Tube Cap for 18mm Tubes, Green

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Culture Tube Cap for 20mm Tubes, Blue

Culture Tube Cap for 20mm Tubes, Clear

Culture Tube Cap for 20mm Tubes, Green

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Culture Tube Cap for 25mm Tubes, Blue

Culture Tube Cap for 25mm Tubes, Clear

Culture Tube Cap for 25mm Tubes, Green

Culture Tube Cap for 25mm Tubes, Red

Culture Tube Cap for 25mm Tubes, Yellow

Culture tube, 10x75mm, 4mL

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Culture tube, 12x75mm (5mL)

Culture tube, 12x75mm (5mL)

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Culture tube, 12x75mm, 6mL

Culture tube, 13x100mm, 10mL

Culture Tube, 14mL, 17 x 100mm, PP, w/ attached 2-position screw-cap, printed graduations, sterile, 10 foam racks of 50 tubes, 500/case

Culture Tube, 14mL, 17 x 100mm, PP, w/ attached 2-position screw-cap, printed graduations, sterile, 20 bags of 25 tubes, 500/case

Culture Tube, 14mL, 17 x 100mm, PP, w/ attached 2-position screw-cap, printed graduations, sterile, individually wrapped, 500/case

Culture Tube, 14mL, 17 x 100mm, PP, w/ separate 2-position screw-cap, non-sterile, non-graduated, 1000 tubes and capped bulk packed separately

Culture Tube, 14mL, 17 x 100mm, PS, w/ attached 2-position screw-cap, printed graduations, sterile, 10 foam racks of 50 tubes, 500/case

Culture Tube, 14mL, 17 x 100mm, PS, w/ attached 2-position screw-cap, printed graduations, sterile, 20 bags of 25 tubes, 500/case

Culture tube, 16x100mm, 14mL

Culture tube, 16x125mm, 19mL

Culture tube, 16x150mm, 23mL

Culture tube, 17x100mm (14mL)

Culture tube, 17x100mm (14mL)

Culture tube, 18x150mm, 29mL

Culture tube, 20x150mm, 36mL

Culture Tube, 5mL, 12 x 75mm, PP, w/ attached 2-position screw-cap, printed graduations, sterile, 10 foam racks of 50 tubes, 500/case

Culture Tube, 5mL, 12 x 75mm, PP, w/ attached 2-position screw-cap, printed graduations, sterile, 20 bags of 25 tubes, 500/case