100g

Ampicillin Sodium Salt

Aniline Blue, Water Soluble

Molecular Formula : C8 H8 O2

Anthracene

Anthracene, Practical

Molecular Formula : C14 H8 O2

Anthraquinone-1,5-disulfonic Acid Disodium Salt

Molecular Formula : C14 H10 O

Anthrone, Reagent, ACS

The product is specific for human CD28.

The product is specific for human CD3.

The product is specific for human CD4.

The product is specific for human CD8.

Antimony Trichloride, Reagent, ACS

Arginine Hydrochloride, USP

Arginine, USP

Ascorbic Acid, Crystalline Powder, FCC

Ascorbic Acid, Reagent, ACS

Aspirin, USP

Atenolol, USP

Auramine O

Aurin Tricarboxylic Acid, [tri]Ammonium Salt, Reagent, ACS

Avobenzone

Azathioprine, USP

Azelaic Acid, Cosmetic Grade

Molecular Formula : C8 H12 N4

Azodicarbonamide

Molecular Formula : C2 H4 N4 O2

Azophloxine

Azure A

b-Nicotinamide Adenine Dinucleotide

b-Sitosterol

B7-1/CD80 and B7-2/CD86, together with their receptors CD28 and CTLA-4, constitute one of the dominant co-stimulatory pathways that regulate T- and B-cell responses. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response. Mature human B7-1 consists of a 208 amino acid extracellular domain (ECD) with two immunoglobulin-like domains, a 21 amino acid transmembrane domain, and a 25 amino acid cytoplasmic domain. Both human and mouse B7-1 and B7-2 can bind to either human or mouse CD28 and sCTLA-4. B7-1 is expressed on activated B cells, activated T cells, and macrophages. B7-2 is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells.

B7-1 and B7-2 are homologous costimulatory ligands expressed on the surface of antigen presenting cells (APCs), both are type 1 transmembrane proteins with a membrane distal IgV and a membrane proximal IgC domain. They share ~25% sequence homology and interact with the same receptors, CD28 and CTLA-4.Binding of these molecules to the T cell costimulatory receptors, CD28 and CTLA-4, is essential for the activation and regulation of T cell immunity. T cell activation requires engagement of the T cell receptor (TCR) with the peptide–MHC complex presented on the cell surface of antigen presenting cells (APCs). In addition to this antigen-specific interaction, a second interaction involving costimulatory receptors (CD28, ICOS) on T cells and their respective ligands (B7-1/B7-2, ICOS-L) on APCs is required for optimal T cell activation. B7-1 and B7-2 may also function to deliver signal into dendritic cells. While B7-1 favors binding to CTLA-4, B7-2 shows a preference for CD28.

Human B7 homolog 3 (B7-H3), a member of the immunoglobulin superfamily, is also known CD276, which contains two Ig-like C2-type (immunoglobulin-like) domains and two Ig-like V-type (immunoglobulin-like) domains. B7-H3 may participate in the regulation of T-cell-mediated immune response. B7-H3 also plays a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. Furthermore, B7-H3 is involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Human B7-H3 does not bind any known members of the CD28 family of immunoreceptor. However, B7-H3 has been shown to bind an unidentified counter-receptor on activated T cells to co-stimulate the proliferation of CD4+ or CD8+ T cells. B7-H3 has also been found to enhance the induction of primary cytotoxic T lymphocytes and stimulate IFN-gamma production.

Human B7 homolog 3 (B7-H3), a member of the immunoglobulin superfamily, is also known CD276, which contains two Ig-like C2-type (immunoglobulin-like) domains and two Ig-like V-type (immunoglobulin-like) domains. B7-H3 may participate in the regulation of T-cell-mediated immune response. B7-H3 also plays a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. Furthermore, B7-H3 is involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Human B7-H3 does not bind any known members of the CD28 family of immunoreceptor. However, B7-H3 has been shown to bind an unidentified counter-receptor on activated T cells to costimulate the proliferation of CD4+ or CD8+ T cells. B7-H3 has also been found to enhance the induction of primary cytotoxic T lymphocytes and stimulate IFN-gamma production.

Baclofen, USP

Barium Bromide, Dihydrate

Barium Chlorate, Monohydrate

Molecular Formula : BaCl2H4O2

Barium Sulfate, USP

Basic Fuchsin

Beclomethasone Dipropionate, Micronized, USP

Beef Extract, Powder

Behenyl Alcohol

Benchmark Agarose LE, 100 g

Molecular Formula : C14 H18 N4 O3

Molecular Formula : C7 H6 O

Benzalkonium Chloride

Benzamide