1mg

Molecular Formula : C28 H46 O

Molecular Formula : C19H22O3

Molecular Formula : C29 H44 O12

Molecular Formula : C29H41D3O12

OX40 (TNFRSF4, CD134) is a member of the tumor necrosis factor (TNF) receptor superfamily that regulates T cell activity and immune responses. The OX40 protein contains four cysteine rich domains, a transmembrane domain, and a cytoplasmic tail containing a QEE motif. OX40 is primarily expressed on activated CD4+ and CD8+ T-cells, while the OX40 ligand (OX40L, TNFSF4, CD252) is predominantly expressed on activated antigen presenting cells. The engagement of OX40 with OX40L leads to the recruitment of TNF receptor-associated factors (TRAFs) and results in the formation of a TCR-independent signaling complex. One component of this complex, PKCθ, activates the NF-κB pathway. OX40 signaling through Akt can also enhance TCR signaling directly. Research studies indicate that the OX40L-OX40 pathway is associated with inflammation and autoimmune diseases. Additional research studies show that OX40 agonists augment anti-tumor immunity in several cancer types.

OX40 is a T cell co-stimulatory molecule of the TNF receptor superfamily that coordinates with other co-stimulators (CD28, CD40, CD30, CD27 and 4-1BB) to manage the activation of the immune response. Tumor necrosis factor ligand superfamily member 4 (TNFSF4) is also known as glycoprotein Gp34, OX40 ligand (OX40L), TAX transcriptionally-activated glycoprotein 1 and CD252, which belongs to the tumor necrosis factor family. TNFSF4 is the ligand for CD134 and is expressed on cells such as DC2s (a subtype of dendritic cells) enabling amplification of Th2 cell differentiation. OX40 is constitutively expressed on Tregs and enhances the sensitivity of Tregs to IL-2, thus promoting Treg proliferation. OX40 has also shown to decrease the cells’ immunosuppressive activity on effector T cells. OX40-OX40 Ligand signaling is involved in allergic airway inflammation, graft-versus-host disease and autoimmune disease.

Molecular Formula : C19 H17 N3 O5 S . 2 Na

Molecular Formula : C19 D5 H13 N3 O5 S . Na

Molecular Formula : C8H4D10N2O4Pt

Molecular Formula : 13C4H4O5

Molecular Formula : C14 H21 N3 O3

Molecular Formula : C7H7D6N3O3S

Molecular Formula : C18H5D10NO3

Molecular Formula : C15 2H5 H6 Cl N2 O2

Molecular Formula : 13C6 C4 H9 N O3

Molecular Formula : C10 D4 H5 N O3

Molecular Formula : C12H18N4O8P2S . x(NH3)

Molecular Formula : C13 2H5 H6 N O5

Molecular Formula : C213C2H2K15N3O4 • xH2O

Molecular Formula : C8¹³C6H12O3

Molecular Formula : C22 H31 N O4

Molecular Formula : C22H22D10ClNO3

Molecular Formula : C22 D11 H20 N O3 . Cl H

Molecular Formula : C13 H9 N3 O

Molecular Formula : C18 D3 H18 N O5

Molecular Formula : C18 2H3 H18 N O4 . Cl H

Molecular Formula : C18 D3 H18 N O4 . Cl H

Molecular Formula : C15 H21 D3 N2 O2

Molecular Formula : C16 2H4 H20 N2 O

Molecular Formula : C21 13C3 H31 F O6

Molecular Formula : C23 H27 N O10

Molecular Formula : C17 2H3 H16 N O4

Molecular Formula : C19 2H9 H11 N2 O3

Molecular Formula : 13C C21 D3 H21 N2 O9 . H Cl

Molecular Formula : C12 H16 N3 O5 P S

Molecular Formula : C45H62D5F3N12O14S2

Molecular Formula : C23H24N4O3

Molecular Formula : C12H13BrF2N3O3P

Molecular Formula : C22H30FNO14

Molecular Formula : C13 H18 O2

Molecular Formula : C7 D6 Br Cl

Molecular Formula : C19 H28 O10

Molecular Formula : C19 D7 H21 O10

Molecular Formula : C7 D4 H4 O

Molecular Formula : C22 H27 F N2 O

Molecular Formula : C22H24D3FN2O

Molecular Formula : C16 H19 N O5

Molecular Formula : C11 H17 N O . Cl H

Molecular Formula : C22 D3 H26 N5 O6

Molecular Formula : C19H28N4O6 . xHCl