1mg

Molecular Formula : C1313C2H10ClN215NO3

Molecular Formula : C9 2H4 H5 Cl2 N3 . Cl H

Molecular Formula : C15H11D4ClN2OS

Molecular Formula : C24H21Cl2NO4S

Molecular Formula : C21 H25 Cl O5

Molecular Formula : C6 2H3 H5 Cl N5 O2 S

Molecular Formula : C5¹³CH5D3ClN5O2S

Molecular Formula : C18 H18 Cl N3 S

Molecular Formula : C18H10D8ClN3S

Molecular Formula : C1513CH12D3ClN2OS

Molecular Formula : C22 D5 H12 Cl N2

Molecular Formula : C15¹³C4H17ClN3NaO5S

Molecular Formula : C18H11D8ClN4O

Molecular Formula : C18 2H4 H15 Cl N4

Molecular Formula : C18H11D8ClN4

Molecular Formula : C24H21F3N6O

Molecular Formula : C12H16O5

Molecular Formula : C12D5H11O5

Molecular Formula : C17H16O5

Ciliary Neurotrophic Factor (CNTF) is a cytokine belonging to the Interleukin 6 (IL-6) family, which also includes IL-6, Oncostatin M, Leukemia Inhibitory Factor (LIF), and Cardiotrophin-1. Structurally, CNTF resembles a four-helix bundle composition, similar to the other members of the IL-6 family. The receptor for CNTF is composed of three parts: a gp130-like subunit common in the IL-6 receptor family, a LIF Receptor β subunit, and a CNTF specific α receptor subunit. Upon binding to the CNTF, the β subunit of the CNTF receptor will undergo tyrosine phosphorylation, and activate the intracellular JAK/STAT pathway. The main function of CNTF in vivo is to promote the differentiation and survival of a variety of neurons and glial cells, including sympathetic precursor cells and spinal motor neurons.

Ciliary neurotrophic factor (CNTF) is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. CNTF was initially identified as a trophic factor for embryonic chick ciliary parasympathetic neurons in culture. Furthermore, the protein is also a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. In addition, CNTF is useful for treatment of motor neuron disease and it could reduce food intake without causing hunger or stress. Recombinant murine CNTF containing 198 amino acids and it shares 82 % and 95 % a.a. sequence identity with human and rat CNTF.

Ciliary Neurotrophic Factor (CNTF) is a polypeptide hormone which acts within the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. CNTF is a potent survival factor for neurons and oligodendrocytes and may play a role in reducing tissue damage during increased inflammation. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, however this phenotype is not causally related to neurologic disease.

Molecular Formula : C17 2H3 H18 N O4

Molecular Formula : C24H28NNaO9

Molecular Formula : C24H23D6NO9

Molecular Formula : C18 2H3 H18 N O3

Molecular Formula : C24 2H3 H25 N O9 . Na

Molecular Formula : C18 2H6 H15 N O3

Molecular Formula : C26 H21 N3 O2

Molecular Formula : C44H72N7O17P3S • x(Na)

Molecular Formula : C54 H82 O4

Molecular Formula : C22 2H3 H22 N O6

Molecular Formula : C22 H19 D6 N O6

Molecular Formula : C12 D9 H10 N O3 . H Cl

Molecular Formula : C20H22O6

Molecular Formula : C27H24F2N4O3

Molecular Formula : C29 H42 O10

Molecular Formula : C10 H15 N3 O8

Molecular Formula : C40H46N4O8

Molecular Formula : C36H3815N4O8

Molecular Formula : C36 H38 N4 O8 . 2Cl 2H

Molecular Formula : C27 H22 O18

Molecular Formula : C24 2H12

Molecular Formula : C208H344N60O63S2 • x(C2HF3O2)

Molecular Formula : C27 H37 O11 . Na

Molecular Formula : C21 2H4 H26 O5

Molecular Formula : C21 D8 H20 O5

Molecular Formula : C16 H18 N2 O6

Molecular Formula : C16H20N2O7

Molecular Formula : C16 H20 N2 O7