1mg

Molecular Formula : C30H43Ca1.5O16S2

Molecular Formula : C53 H72 N2 O12 . 2 C6 H5 O3 S

Molecular Formula : C29 H42 N O7 . C6 H5 O3 S

Molecular Formula : C18H30N8O6S

Molecular Formula : C8 2H5 H9 Cl N5

Molecular Formula : C40H67N5O8 • x(C2HF3O2)

Molecular Formula : C16H13NO5

Molecular Formula : C16H13NO6

Molecular Formula : C49H74O14

Molecular Formula : C48H72O14

Molecular Formula : C7 H10 N3 O6 S . Na

Molecular Formula : C19 H20 I N3 O

Molecular Formula : C22 D3 H15 N4 O S

Molecular Formula : C25H34N4O2 • 2(HCl)

Molecular Formula : C27H31N7O2 . HCl

Molecular Formula : C33 H42 O14

Molecular Formula : C34H44O14

Molecular Formula : C28 H34 O5

Molecular Formula : C9 D6 H4 Cl N2 O5 P S

Molecular Formula : C16 H20 N4 O2

Molecular Formula : C17 2H3 H17 Cl N3 O3 . Cl H

Molecular Formula : C9H4D3N7O2S

Molecular Formula : C21 H25 Cl N6 O2

Molecular Formula : C20H24N6O2S

Molecular Formula : No Data Available

Molecular Formula : C2113CH21D3ClN3O2

Molecular Formula : C15H20N6O4

Molecular Formula : C18 H35 N3 O2

Molecular Formula : C29 H26 N4 O7

Molecular Formula : C25 H15 D5 N4 O5

Molecular Formula : C26H17D5N4O5

Molecular Formula : C23H22D8Cl3N5O3

Molecular Formula : C38H72N2O11

Molecular Formula : C3713CH69D3N2O12

Molecular Formula : C38 2H3 H69 N2 O12

Molecular Formula : C38H67D5N2O12

Molecular Formula : C22 2H4 H13 N3 O5

Molecular Formula : C20H34O2

Molecular Formula : C18¹³C2H27N4O12P.NH3

Molecular Formula : C20H17ClN4O3

B7-1/CD80 and B7-2/CD86, together with their receptors CD28 and CTLA-4, constitute one of the dominant co-stimulatory pathways that regulate T- and B-cell responses. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response. Mature human B7-1 consists of a 208 amino acid extracellular domain (ECD) with two immunoglobulin-like domains, a 21 amino acid transmembrane domain, and a 25 amino acid cytoplasmic domain. Both human and mouse B7-1 and B7-2 can bind to either human or mouse CD28 and sCTLA-4. B7-1 is expressed on activated B cells, activated T cells, and macrophages. B7-2 is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells.

B7-1 and B7-2 are homologous costimulatory ligands expressed on the surface of antigen presenting cells (APCs), both are type 1 transmembrane proteins with a membrane distal IgV and a membrane proximal IgC domain. They share ~25% sequence homology and interact with the same receptors, CD28 and CTLA-4.Binding of these molecules to the T cell costimulatory receptors, CD28 and CTLA-4, is essential for the activation and regulation of T cell immunity. T cell activation requires engagement of the T cell receptor (TCR) with the peptide–MHC complex presented on the cell surface of antigen presenting cells (APCs). In addition to this antigen-specific interaction, a second interaction involving costimulatory receptors (CD28, ICOS) on T cells and their respective ligands (B7-1/B7-2, ICOS-L) on APCs is required for optimal T cell activation. B7-1 and B7-2 may also function to deliver signal into dendritic cells. While B7-1 favors binding to CTLA-4, B7-2 shows a preference for CD28.

Human B7 homolog 3 (B7-H3), a member of the immunoglobulin superfamily, is also known CD276, which contains two Ig-like C2-type (immunoglobulin-like) domains and two Ig-like V-type (immunoglobulin-like) domains. B7-H3 may participate in the regulation of T-cell-mediated immune response. B7-H3 also plays a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. Furthermore, B7-H3 is involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Human B7-H3 does not bind any known members of the CD28 family of immunoreceptor. However, B7-H3 has been shown to bind an unidentified counter-receptor on activated T cells to co-stimulate the proliferation of CD4+ or CD8+ T cells. B7-H3 has also been found to enhance the induction of primary cytotoxic T lymphocytes and stimulate IFN-gamma production.

Human B7 homolog 3 (B7-H3), a member of the immunoglobulin superfamily, is also known CD276, which contains two Ig-like C2-type (immunoglobulin-like) domains and two Ig-like V-type (immunoglobulin-like) domains. B7-H3 may participate in the regulation of T-cell-mediated immune response. B7-H3 also plays a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. Furthermore, B7-H3 is involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Human B7-H3 does not bind any known members of the CD28 family of immunoreceptor. However, B7-H3 has been shown to bind an unidentified counter-receptor on activated T cells to costimulate the proliferation of CD4+ or CD8+ T cells. B7-H3 has also been found to enhance the induction of primary cytotoxic T lymphocytes and stimulate IFN-gamma production.

Molecular Formula : C10 2H4 H8 Cl N O2

Molecular Formula : C10 2H4 H8 Cl N O2

BAFF Receptor (BAFF-R), a member of the TNFR superfamily, is highly expressed in spleen, lymph node, and resting B cells and to some extent in activated B cells, resting CD4+ cells and peripheral blood leukocytes. BAFF-R is a type III transmembrane protein that binds with high specificity to BAFF (TNFSF13B). BAFF-R/BAFF signaling plays a critical role in B cell survival and maturation.

B-cell activating factor, also known as BAFF, TALL-1, TNAK, and zTNF4, is a member of theTNF ligand superfamily designated TNFSF13B. Produced by macrophages, dendritic cells, and T lymphocytes, BAFF promotes the survival of B cells and is essential for B cell maturation. BAFF binds to three TNF receptor superfamily members: B-cell maturation antigen (BCMA/TNFRSF17), transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI/TNFRSF13B) and BAFF receptor (BAFF R/BR3/TNFRSF 13C). These receptors are type III transmembrane proteins lacking a signal peptide. Whereas TACI and BCMA bind BAFF and another TNF superfamily ligand, APRIL(a proliferation-inducing ligand), BAFF R selectively binds BAFF. The BAFF R extracellular domain lacks the TNF receptor canonical cysteine-rich domain (CRD) and contains only a partial CRD with four cysteine residues. Human and mouse BAFF R share 56% aa sequence identity. BAFF R is highly expressed in spleen, lymph node and resting B cells. It is also expressed at lower levels in activated B cell, resting CD4+ T cells, thymus and peripheral blood leukocytes.

Molecular Formula : C35H58O9

Molecular Formula : C44H65NO13