1mg

Molecular Formula : C20H27N5O3

Molecular Formula : C31H41NO4

Molecular Formula : C20H21N7O

Molecular Formula : C24H16F4N6O2

Molecular Formula : C30 H34 N2 O4

Molecular Formula : C30 H30 D4 N2 O3

Molecular Formula : C16H19NO2

CXCL13, also known as B-lymphocyte chemoattractant (BLC), is a CXC chemokine that is constitutively expressed in secondary lymphoid organs. BCA-1 cDNA encodes a protein of 109 amino acid residues with a leader sequence of 22 residues. Mature human BCA-1 shares 64% amino acid sequence similarity with the mouse protein and 23 – 34% amino acid sequence identity with other known CXC chemokines. Recombinant or chemically synthesized BCA-1 is a potent chemoattractant for B lymphocytes but not T lymphocytes, monocytes or neutrophils. BLR1, a G protein-coupled receptor originally isolated from Burkitt’s lymphoma cells, has now been shown to be the specific receptor for BCA-1. Among cells of the hematopoietic lineages, the expression of BLR1, now designated CXCR5, is restricted to B lymphocytes and a subpopulation of T helper memory cells. Mice lacking BLR1 have been shown to lack inguinal lymph nodes. These mice were also found to have impaired development of Peyer’s patches and defective formation of primary follicles and germinal centers in the spleen as a result of the inability of B lymphocytes to migrate into B cell areas.

BCMA, a member of the TNF receptor superfamily, binds to BAFF and APRIL. BCMA is expressed on mature B-cells and other B-cell lines and plays an important role in B cell development, function and regulation. BCMA also has the capability to activate NF-kappaB and JNK. The human BCMA gene codes for a 184 amino acid type I transmembrane protein, which contains a 54 amino acid extracellular domain, a 23 amino acid transmembrane domain, and a 107 amino acid extracellular domain.

Molecular Formula : C13 D8 H10 Cl2 N2

Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The α-defensins are distinguished from the β-defensins by the pairing of their three disulfide bonds. To date, four human β-defensins have been identified; BD-1, BD-2, BD-3 and BD-4. β-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they are chemoattractant towards immature dendritic cells and memory T cells. The β-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence and, in the case of BD-1 (36 a.a.), a propeptide region. β-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. β-Defensins are 3-5 kDa peptides ranging in size from 33-47 amino acid residues.

Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The α-defensins are distinguished from the β-defensins by the pairing of their three disulfide bonds. To date, four human β-defensins have been identified; BD-1, BD-2, BD-3 and BD-4. β-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they are chemoattractant towards immature dendritic cells and memory T cells. The β-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence and, in the case of BD-1 (36 a.a.), a propeptide region. β-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. β-Defensins are 3-5 kDa peptides ranging in size from 33-47 amino acid residues.

Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The α-defensins are distinguished from the β-defensins by the pairing of their three disulfide bonds. To date, four human β-defensins have been identified; BD-1, BD-2, BD-3 and BD-4. β-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they are chemoattractant towards immature dendritic cells and memory T cells. The β-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence and, in the case of BD-1 (36 a.a.), a propeptide region. β-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. β-Defensins are 3-5 kDa peptides ranging in size from 33-47 amino acid residues.

Molecular Formula : C6 13C6 H7 Br3 O

Molecular Formula : C45 H57 N3 O9

Molecular Formula : C25 H33 Cl O6

Molecular Formula : C25H28D5ClO6

Molecular Formula : C27 H35 Cl O7

Molecular Formula : C29H39ClO7

Molecular Formula : C25 H33 Cl O6

Molecular Formula : C25H28D5ClO6

Molecular Formula : C28D10H27ClO7

Molecular Formula : C22H24D5ClO5

Molecular Formula : C32 2H6 H25 Br N2 O2

Molecular Formula : C21H22N2O10S

Molecular Formula : C29H41NO6

Molecular Formula : C25H21D7ClN3O4

Molecular Formula : C30H36N2O11

Molecular Formula : C24H24D5ClN2O5

Molecular Formula : C28H32N2O11

Molecular Formula : C22H19D5N2O5

Molecular Formula : C19 H27 Cl2 N3 O2

Molecular Formula : C16H16D6Cl3N3O2

Molecular Formula : C19H21ClF3NO2

Molecular Formula : C26H27N4O7PS

Molecular Formula : C16 H12 Cl N O3

Molecular Formula : C10 D7 H5 N2 O3 S

Molecular Formula : C18D11HO

Molecular Formula : C18 D4 H6 O2

Molecular Formula : 13C2 C18 D2 H10 O . 13C2 C18 D2 H9 O

Molecular Formula : 2 C20 H12

Molecular Formula : 2 13C2 C18 D2 H10

Molecular Formula : C20H12O

Molecular Formula : C12 2H8 H4 N2

Molecular Formula : C12H5D7N4O3

Molecular Formula : C20 H10 O2

Molecular Formula : C20 H10 O2

Molecular Formula : C22 2H12

Molecular Formula : 13C6 C H5 N O S

Molecular Formula : C30 D10 H19 N3 O