1mg

Molecular Formula : C23 H22 Cl N O2

Molecular Formula : C14 2H10 H12 N2 O

Molecular Formula : C14H17D6ClN2O

Molecular Formula : C37H42N2O6

Leukemia Inhibitory Factor (LIF) is a pleiotropic cytokine belonging to the long four-helix bundle cytokine superfamily. LIF shares tertiary structure with several other cytokines, including Interleukin-6 (IL-6), Oncostatin M, ciliary neurotropic factor, and cardiotrophin-1, and their functions in vivo are also redundant to some extent. LIF can bind to the common receptor of IL-6 subfamily, gp130, and then recruit its own receptor LIF Receptor to form a ternary complex. The basal expression of LIF in vivo is low; and its expression is induced by pro-inflammatory factors, including lipopolysaccharide, IL-1, and IL-17, and inhibited by anti-inflammatory agents, including IL-4 and IL-13. The functions of LIF include proliferation of primordial germ cells, regulation in blastocyst implantation and early pregnancy, and maintenance of pluripotent embryonic stem cells.

Leukemia Inhibitory Factor (LIF) is a pleiotropic cytokine belonging to the long four-helix bundle cytokine superfamily. LIF shares tertiary structure with several other cytokines, including Interleukin-6 (IL-6), Oncostatin M, ciliary neurotropic factor, and cardiotrophin-1, and their functions in vivo are also redundant to some extent. LIF can bind to the common receptor of IL-6 subfamily, gp130, and then recruit its own receptor LIF Receptor to form a ternary complex. The basal expression of LIF in vivo is low; and its expression is induced by pro-inflammatory factors, including lipopolysaccharide, IL-1, and IL-17, and inhibited by anti-inflammatory agents, including IL-4 and IL-13. The functions of LIF include proliferation of primordial germ cells, regulation in blastocyst implantation and early pregnancy, and maintenance of pluripotent embryonic stem cells.

LIGHT, also known as tumor-necrosis factor (TNF) superfamily member 14 (TNFSF14), is predominantly expressed on activated immune cells and some tumor cells. LIGHT (homologous to lymphotoxin, exhibits inducible expression and competes with Herpes Simplex Virus glycoprotein D for Herpes Virus Entry Mediator, a receptor expressed by T cells), is a protein primarily expressed on activated T cells, activated Natural Killer (NK) cells, and immature dendritic cells (DC). LIGHT can function as both a soluble and cell surface-bound type II membrane protein and must be in its homotrimeric form to interact with its two primary functional receptors: Herpes Virus Entry Mediator (HVEM) and Lymphotoxin-β Receptor (LTβR). LIGHT signaling through these receptors have distinct functions that are cell-type dependent, but interactions with both types of receptors have immune-related implications in tumor biology.

Molecular Formula : C12 H14 O2

Molecular Formula : C22 H36 O5

Molecular Formula : C17 H14 Cl2 F2 N4 O S

Molecular Formula : C27 D3 H27 N8 O3

Molecular Formula : C51 H56 N16 O4

Molecular Formula : C25 D3 H25 N8 O2

Molecular Formula : C10 H18 O2

Molecular Formula : C18H35N2O9PS

Molecular Formula : C17H32N2O6S

Molecular Formula : C17H33ClN2O6S

Molecular Formula : C35H51N11O9S2. x C2F3OOH

Molecular Formula : C21 H18 F N5 O

Molecular Formula : C15 H25 N3 O . 2 Cl H

Molecular Formula : C15H24D3Cl2N3O

Molecular Formula : C20H26N4O •C4H4O4

Molecular Formula : C30 H48 O9

Molecular Formula : C30H48O9

Molecular Formula : C24 2H4 H36 O3

Molecular Formula : C24H35D5O3

Molecular Formula : C26H38D5NO4

The mouse homolog of ENA-78 is called LIX. ENA-78/LIX is a CXC chemokine that signals through the CXCR2 receptor. It is expressed in monocytes, platelets, endothelial cells, and mast cells. ENA-78/LIX is a chemoattractant for neutrophils. The three naturally occurring variants of human ENA-78; ENA 5-78, ENA 9-78 and ENA 10-78, contain 74, 70, and 69 amino acid residues, respectively, and possess the same biological activity. ENA-78/LIX contains the four conserved cysteine residues present in CXC chemokines, and also contains the ‘ELR’ motif common to CXC chemokine that bind to the CXCR1 and CXCR2 receptors.

Molecular Formula : C20H28O8

Molecular Formula : C11H15N5O3

Molecular Formula : C11H4D2ClN15N2O6

Molecular Formula : C25H32N2O3

Molecular Formula : C27H34N2O7

Molecular Formula : C26H24D3ClN2O

Molecular Formula : C11 2H4 H8 Cl2 N2

Molecular Formula : C21 H25 N5 O6 . x[H2 O]

Molecular Formula : C29H27D6ClN2O2 . HCl

Molecular Formula : C37H46N4O6

Molecular Formula : C37 H48 N4 O6

Molecular Formula : C37 D8 H40 N4 O5

Molecular Formula : C23 H21 Cl N6 O3

Molecular Formula : C23H13D8ClN6O3

Molecular Formula : C16 H16 Cl N3 O4 . H2 O

Molecular Formula : C22H19D4ClN2O2

Molecular Formula : C22H19D4ClN2O4

Molecular Formula : C22H18D5ClN2O2

Molecular Formula : C22 D5 H18 Cl N2 O2

Molecular Formula : C21H18Cl2N2O8

Molecular Formula : C22 D3 H18 Cl N6 O

Molecular Formula : C22 H21 Cl N6 O2