1mg

Macrophage Migration Inhibitory Factor (MIF) is a pleiotropic cytokine, existing as a homotrimer in vivo. MIF was originally identified as a T cell derived factor responsible for the inhibition of macrophage migration. However, recently MIF has received much more attention because of its possible roles in angiogenesis and cancer development. MIF is over-expressed in various cancers, including pancreatic, breast, colon, brain, prostate, skin, and lung. The intratumoral expression of MIF is strongly correlated with angiogenic growth factor expression, such as the expression of Interleukin 8 (IL-8) and Vascular Endothelial Growth Factor (VEGF), and with risk of recurrence after resection.

Macrophage migration inhibitory factor (MIF or MMIF), also named as glycosylation-inhibiting factor (GIF), L-dopachrome isomerase, or phenylpyruvate tautomerase, is a protein encoded by the MIF gene. It is released from white blood cells by bacterial antigen stimulation to trigger an acute immune response, or by glucocorticoids to counter-act the inhibitory effects of glucocorticoids on immune system. MIF is a homotrimer of which each subunit contains 115 amino acids. As mentioned above, MIF is involved in the innate immune response to bacterial pathogens and counter-acts the anti-inflammatory activity of glucocorticoids. Furthermore, it also plays a role as mediator in regulating the function of macrophages in host defense and has phenylpyruvate tautomerase and dopachrome tautomerase activity in vitro. Mouse MIF is active on human cells, while human MIF is active on mouse cells. Mouse MIF is 99 %, 84 %, 90 %, and 90 % a.a. identical to rat, porcine, bovine and human MIF, respectively.

Chemokine (C-X-C motif) ligand 9 (CXCL9), also known as monokine induced by interferon gamma (MIG), is a small cytokine belonging to the CXC chemokine family. The CXCL9 gene is induced in macrophages and in primary glial cells of the central nervous system specifically in response to IFNγ. CXCL9 has been shown to be a chemoattractant for activated T-lymphocytes and TIL but not for neutrophils or monocytes. The human CXCL9 cDNA encodes a 125 amino acid residue precursor protein with a 22 amino acid residue signal peptide that is cleaved to yield a 103 amino acid residue mature protein. CXCL9 has an extended carboxy-terminus containing greater than 50% basic amino acid residues and is larger than most other chemokines. A chemokine receptor (CXCR3) specific for CXCL9 and IP-10 has recently been cloned and shown to be highly expressed in IL-2-activated T-lymphocytes.

Chemokine (C-X-C motif) ligand 9 (CXCL9), also known as monokine induced by interferon gamma (MIG), is a small cytokine belonging to the CXC chemokine family.The CXCL9 gene is induced in macrophages and in primary glialcells of the central nervous systemin response to IFN­γ. CXCL9 has been shown to be achemo attractant for activated Th1lymphocytes and tumor-infiltrating leukocytes (TILs) but not for neutrophils or monocytes. CXCL is also involved in other cellular activities including inhibition of tumor growth, angiogenesis, and inhibition of colony formation of hematopoietic progenitors. CXCL9 is closely related to two other CXC chemokines, CXCL10 and CXCL11.CXCL9, CXCL10 and CXCL11 all elicit their chemotactic functions by interacting with the chemokine receptor CXCR3.

Human Chemokine (C-C Motif) Ligand 3 (CCL3) is a small cytokine belonging to the CC chemokine family. CCL3 is primarily expressed in T cells, B cells, and monocytes after antigen or mitogen stimulation. CCL3 exhibits chemoattractive and adhesive effects on lymphocytes. CCL3 exerts multiple effects on hematopoietic precursor cells and inhibits the proliferation of hematopoietic stem cells in vitro as well as in vivo. CCR1 and CCR5 have been identified as functional receptors for CCL3.

Chemokine (C-X-C motif) ligand 2 (CXCL2) is a small cytokine belonging to the CXC chemokine family that is also referred to as macrophage inflammatory protein 2-alpha (MIP2-alpha), Growth-regulated protein beta (Gro-beta) and Gro oncogene-2 (Gro-2). CXCL2 is secreted by monocytes and macrophages and is chemotactic for polymorphonuclear leukocytes and hematopoietic stem cells. CXCL2’s amino acid sequence is 90% identical to the amino acid sequence of related chemokine, CXCL1. CXCL2 signals through the CXCR2 receptor.

Macrophage Inflammatory Protein-3 (MIP-3α), also known as chemokine (C-C motif) ligand 20 (CCL20) or liver activation regulated chemokine (LARC), is a small cytokine belonging to the CC chemokine family. MIP-3α is expressed in the liver, lymph nodes, appendix, PBL and lung and can signal through the CCR6 receptor. It is strongly chemotactic for lymphocytes and weakly attracts neutrophils. MIP-3α is implicated in the formation and function of mucosal lymphoid tissues via chemoattraction of lymphocytes and dendritic cells toward the epithelial cells surrounding these tissues. Additionally, it promotes the adhesion of memory CD4+ T cells and inhibits colony formation of bone marrow myeloid immature progenitors.

Macrophage Inflammatory Protein-3 (MIP-3α), also known as chemokine (C-C motif) ligand 20 (CCL20) or liver activation regulated chemokine (LARC), is a small cytokine belonging to the CC chemokine family. MIP-3α is expressed in the liver, lymph nodes, appendix, PBL and lung and can signal through the CCR6 receptor. It is strongly chemotactic for lymphocytes and weakly attracts neutrophils. MIP-3α is implicated in the formation and function of mucosal lymphoid tissues via chemoattraction of lymphocytes and dendritic cells toward the epithelial cells surrounding these tissues. Additionally, it promotes the adhesion of memory CD4+ T cells and inhibits colony formation of bone marrow myeloid immature progenitors.

Macrophage Inflammatory Protein-3 (MIP-3α), also known as chemokine (C-C motif) ligand 20 (CCL20) or liver activation regulated chemokine (LARC), is a small cytokine belonging to the CC chemokine family. MIP-3α is expressed in the liver, lymph nodes, appendix, PBL and lung and can signal through the CCR6 receptor. It is strongly chemotactic for lymphocytes and weakly attracts neutrophils. MIP-3α is implicated in the formation and function of mucosal lymphoid tissues via chemoattraction of lymphocytes and dendritic cells toward the epithelial cells surrounding these tissues. Additionally, it promotes the adhesion of memory CD4+ T cells and inhibits colony formation of bone marrow myeloid immature progenitors.

CCL18, is a novel CC chemokine that is highly homologous to MIP-1α (61% amino acid sequence identity). CCL18 cDNA encodes an 89 aa residue precursor protein with a 20 aa putative signal peptide that is cleaved to generate a 69 aa residue mature protein which lacks potential glycosylation sites. In vitro, CCL18 mRNA expression is induced in alternatively activated macrophages by Th2 cytokines such as IL-4, IL-10 and IL-13, and inhibited by IFN-γ. CCL18 mRNA is also expressed by GM-CSF/IL-4-induced monocyte-derived dendritic cells. In vivo, CCL18 is highly expressed in lung and placenta but is not expressed in epidermal Langerhans cells. Recombinant CCL18 has been shown to chemoattract naive T cells, but not monocytes or neutrophils.

Molecular Formula : C74H60NO4P2 • Br

The A29L protein from Monkeypox binds to cell surface heparin to promote fusion of viral membrane with host plasma membrane, it is a potential target for developing diagnosis and vaccine.

The L1R protein from Monkeypox is crucial for viral growth and virion morphogenesis, it is a potential target for developing diagnosis and vaccine.

Molecular Formula : CH5AsO2S

Rabbit anti-mouse monoclonal antibody is a secondary antibody which recognizes mouse immunoglobulins with high affinity. It is a useful tool for the detection, sorting, capture or purification of its specified target. It can be used in several analysis systems such as ELISA or Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS) and Time-resolved fluorescence immunoassay (TRFIA). It also can be used to develop secondary antibody-coupled magnetic beads for immunoprecipitation (IP), Co-IP, and isolation of cells.

Anti-Müllerian hormone (AMH) is a glycoprotein dimer. It is a member of the transforming growth factor-β superfamily. AMH is a hormone produced by small follicles in the ovary. It is a novel fertility marker to assess ovarian reserve levels.

Biotin is widely conjugated to proteins and antibodies for biochemical assays. Avidin (streptavidin)-biotin system is commonly used for many immunoassays such as ELISA, Flow Cytometry, Immunofluorescence, In Situ Hybridization, and Immunohistochemistry. Anti-Biotin mAb is a better alternative to avidins to minimize background and maximize signal intensity.

Fluorescein isothiocyanate (FITC) is a derivative of fluorescein used in wide-ranging applications including flow cytometry. It is the original fluorescein molecule functionalized with an isothiocyanate reactive group (-N=C=S), replacing a hydrogen atom on the bottom ring of the structure. This derivative is reactive towards nucleophiles including amine and sulfhydryl groups on proteins.

Interleukin-6 (IL6) is a multi-functional cytokine, produced by variety of cells including T-cells, B-cells, monocytes, fibroblasts, keratinocytes, endothelial cells, mesangial cells, astrocytes and bone marrow stroma cells. It is involved in the induction of B-cell differentiation, growth promotion of myeloma cells and proliferation and differentiation of T cells. IL6 can regulate immune responses, acute phase reactions and hematopoiesis.

MSH6, also known as MutS protein homolog 6, is a member of the Mutator S (MutS) family of proteins. It functions to repair mutations during DNA replication. MSH6 is a useful in diagnostics of gastrointestinal tract cancer.

BNP and NT-proBNP are separated from precursor molecule proBNP via proteolytic processing. The BNP and NT-proBNP level in blood are proportional to the severity of cardiac dysfunction. They can be used for diagnosis of congestive heart failure (CHF).

BNP and NT-proBNP are separated from precursor molecule proBNP via proteolytic processing. The BNP and NT-proBNP level in blood are proportional to the severity of cardiac dysfunction. They can be used for diagnosis of congestive heart failure (CHF).

It is type I transmembrane glycoprotein that belongs to the B7 family. PD-L1 is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. It plays a role in regulating T cell responses. The interaction of PD-L1 with PD-1 inhibits T cell proliferation and cytokine production.

It is type I transmembrane glycoprotein that belongs to the B7 family. PD-L1 is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. It plays a role in regulating T cell responses. The interaction of PD-L1 with PD-1 inhibits T cell proliferation and cytokine production.

The product is specific for SARS-CoV-2 Spike Protein S1 subunit and its RBD domain.

The product is specific for SARS-CoV-2 Spike Protein S1 subunit and its RBD domain.

The product is specific for SARS-CoV-2 Spike Protein S1 subunit and its RBD domain. The product can recognize and neutralize Wild-Type SARS-CoV-2 and Variants of Concern (VOC) including Alpha, Beta, Delta, and Omicron. Reactivity with Gamma variant has not been tested.

The product is specific for SARS-CoV-2 Spike Protein S1 subunit and its RBD domain. The product can recognize and neutralize Wild-Type SARS-CoV-2 and five Variants of Concern (VOC) including Alpha, Beta, Gamma, Delta, and Omicron.

GenScript MonoRab™ SARS-CoV-2 Spike (417N) Neutralizing Antibody (21F1), mAb, Rabbit is specific for 417N site of B.1.351 (SARS-CoV-2 Beta VOC) RBD. This product can recognize RBD single mutant (K417N) and RBD triple mutant (K417N, E484K, and N501Y), but can’t recognize the wild type RBD, RBD single mutant (N501Y), and RBD single mutant (E484K).

The product is specific for SARS-CoV-2 Spike Protein S1 subunit and its RBD domain.

GenScript Purified Mouse IgG (Whole Molecule) Control is highly purified from normal mouse serum through Protein A chromatography.GenScript Purified Mouse IgG (Whole Molecule) Control is suitable to be used as control, standard, blocking agent, or coating protein in a variety of assays, including ELISA, immunobloting (Dot blot and Western blot), immunoprecipitation, immunodiffusion, and immunoelectrophoresis.It may also be used as antigen or ligand in immunochemical conjugation reaction.

Mouse IgG1 control (Whole Molecule), Purified is suitable to be used as control, standard, blocking agent, or coating protein in a variety of assays, including ELISA, FACS, ICC immunoblotting, Dot blot, Western blot, immunoprecipitation, immunodiffusion, and immunoelectrophoresis.It may also be used as antigen or ligand in immunochemical conjugation reaction.GenScript Mouse IgG1 control (Whole Molecule), Purified is highly purified from culture supernatant from roller bottle through Protein A affinity column.GenScript Mouse IgG1 control (Whole Molecule), Purified is produced from the hybridoma resulting from fusion of SP2/0-Ag14 myeloma and B-lymphocytes.

Mouse IgG2a control (Whole Molecule), Purified is suitable to be used as control, standard, blocking agent, or coating protein in a variety of assays, including ELISA, FACS, ICC immunoblotting, Dot blot, Western blot, immunoprecipitation, immunodiffusion, and immunoelectrophoresis. It may also be used as antigen or ligand in immunochemical conjugation reaction.GenScript Mouse IgG2a control (Whole Molecule), Purified is highly purified from cell culture in vitro under conditions free from animal-derived components through Protein A affinity column.

Mouse IgG2b control (Whole Molecule), Purified is suitable to be used as control, standard, blocking agent, or coating protein in a variety of assays, including ELISA, immunobloting (Dot blot and Western blot), immunoprecipitation, immunodiffusion, and immunoelectrophoresis. It may also be used as antigen or ligand in immunochemical conjugation reaction. GenScript Mouse IgG2b control (Whole Molecule)is highly purified from normal mouse ascites through Protein A affinity column and produced from the hybridoma resulting from fusion of SP2/0-Ag14 myeloma and B-lymphocytes.

Molecular Formula : C6 2H6 H6 O6

Molecular Formula : C6D6Na6O21P6

Myoglobin (symbol Mb or MB) is an iron-and oxygen-binding protein. Its level in blood increases above normal levels at the beginning of myocardial necrosis associated with myocardial infarction (MI). It is used as a diagnosis marker for skeletal or myocardial muscle injury.

Myoglobin (symbol Mb or MB) is an iron-and oxygen-binding protein. Its level in blood increases above normal levels at the beginning of myocardial necrosis associated with myocardial infarction (MI). It is used as a diagnosis marker for skeletal or myocardial muscle injury.

Myoglobin (symbol Mb or MB) is an iron-and oxygen-binding protein. Its level in blood increases above normal levels at the beginning of myocardial necrosis associated with myocardial infarction (MI). It is used as a diagnosis marker for skeletal or myocardial muscle injury.

Myoglobin (symbol Mb or MB) is an iron-and oxygen-binding protein. Its level in blood increases above normal levels at the beginning of myocardial necrosis associated with myocardial infarction (MI). It is used as a diagnosis marker for skeletal or myocardial muscle injury.

Molecular Formula : C19H19D9Cl2FN3O2

Molecular Formula : C16H11F3N6O5

Molecular Formula : C27H21N5

Molecular Formula : C8H18ClNO5

Molecular Formula : C8H18ClNO5

Molecular Formula : C9H2D9NO

Molecular Formula : 13C6 C6 H9 Cl2 N

Molecular Formula : C22H22N6O4

Molecular Formula : C21H26BrNO4