5g

Maleimide

Maltotriose

Mannan

CCL2, also known as monocyte chemotactic and activating factor (MCAF), was initially purified independently by two groups based on its ability to chemoattract monocytes. Subsequent to its cloning and sequencing, it became evident that this protein is also identical to the product of the human JE gene. The JE gene, originally identified in mouse fibroblasts, is a plateletderived growth factor (PDGF)inducible gene. The human CCL2 cDNA encodes a 99 amino acid residue precursor protein with a 23 residue hydrophobic signal peptide that is cleaved to generate the 76 residue mature protein. Natural CCL2 is heterogeneous in size due to the addition of Olinked carbohydrates and sialic acid residues. In addition to fibroblasts; tumor cells, smooth muscle cells, endothelial cells, and mononuclear phagocytes can also produce CCL2 either constitutively or upon stimulation by various stimuli. CCL2 is a member of the β (CC) subfamily of chemokines. Recently, the existence of MCP2 and MCP3 with 62% and 73% amino acid identity respectively, to CCL2 have been reported.

Chemokine (C-C motif) ligand 2 (CCL2) is also referred to as monocyte chemotactic protein 1 (MCP1) and small inducible cytokine A2. CCL2 is a small cytokine that belongs to the CC chemokine family. CCL2 recruits monocytes, memory T cells, and dendritic cells to the sites of inflammation produced by either tissue injury or infection. CCL2 is implicated in the pathogeneses of several types of disease characterized by monocytic infiltrates, such as psoriasis, rheumatoid arthritis and atherosclerosis. CCL2 is anchored in the plasma membrane of endothelial cells by glycosaminoglycan side chains of proteoglycans. CCL2 is primarily secreted by monocytes, macrophages and dendritic cells. CCL2 can signal through the CCR2 receptor.

Mebendazole

Meclofenamate Sodium, USP

Mecobalamin, JP

Melatonin

Melatonin, Powder

Meldola’s Blue

Melibiose, Hydrate

Mellitic Acid

Meloxicam, USP

Meperidine Hydrochloride (CII), USP

Meropenem

Mesityl Chloride

meso-Erythritol

meso-Hydrobenzoin

Mesotartaric Acid, Monohydrate

Metacresol Purple Sodium Salt

Metalphthalein, Reagent, ACS

Methacholine Chloride, High Purity

Methadone Hydrochloride (CII), USP

Methanesulfonic Acid Ethyl Ester

Methotrexate, USP

Methoxyamine Hydrochloride

Methoxybenzoquinone

Methyl (R)-(-)-3-Hydroxyisobutyrate

Methyl (S)-(-)-2-Isocyanato-3-methylbutyrate

Methyl (Triphenylphosphoranylidene)acetate

Methyl 2-(Bromomethyl)-3-nitrobenzoate

Methyl 2-(Bromomethyl)acrylate

Methyl 2-Chloronicotinate

Molecular Formula : C9H10O3

Methyl 2-Oxo-1-pyrrolidineacetate

Methyl 2,3,6-Tri-O-benzoyl-alpha-D-galactopyranoside

Methyl 2,4-Dihydroxybenzoate

Methyl 3-Bromo-2-(bromomethyl)propionate

Methyl 3,5-Diamino-6-chloropyrazine-2-carboxylate

Methyl Alcohol-d4, 99.8 Atom Percent D

Methyl Arachidate

Methyl beta-D-Ribofuranoside

Methyl Bromodifluoroacetate

Methyl Coumalate

Methyl Green Zinc Chloride Salt

Methyl Heptadecanoate

Methyl Jasmonate, (mixture of isomers)

Methyl Lignocerate

Methyl Malonyl Chloride