ABflo® 647 Rabbit anti-Human Megalin/LRP2 mAb

$591.36

Weight 3 lbs
Dimensions 5 × 5 × 5 in
Brand

Size/Quantity

Product Size

Shipping Condition

Manufacturer Part No

SKU: Abclonal-A24716 Category:

Description

The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).

Please Submit Your Inquiries Below
Name(Required)
This field is for validation purposes and should be left unchanged.

What Makes Us Unique?

The Adva Tech portfolio offers a comprehensive workflow for your manufacturing needs with wide range of services that includes on site Inventory Management, Procurement Management, and Manufacturing Capabilities such as custom pack and private labeling.

Every client in the life science reagents and chemicals industry has unique needs and deserve unique solutions.

By partnering with the Adva Tech team, you will be supported throughout the life cycle of your product. This collaboration results in building better products, increasing efficiencies, and reducing cost & waste.

Adva Tech team is committed to your success and ready to help your company meet and exceed expectations.

Learn More