Simultaneously separate pharmaceutical drug substances and their counterions with high-efficiency Thermo Scientific™ Acclaim™ Trinity P1 LC Columns. A unique trimodal surface chemistry provides concurrent reversed-phase, cation-exchange and anion-exchange functionalities for maximum flexibility in method development. Easily optimize selectivity by adjusting mobile phase buffer concentration, pH and solvent content-either jointly or independently-to accelerate chromatographic separations and increase productivity.

The Acclaim Trinity P1 stationary phase, based on Nanopolymer Silica Hybrid (NSH) technology, consists of high-purity porous, spherical 3 m silica particles, coated with charged nanopolymer beads. The unique surface chemistry includes an inner-pore area modified with an organic layer that provides both reversed-phase and anion-exchange properties. The outer-pore surface, conversely, is modified with cation-exchange functionality for unparalleled chromatographic performance.

Superior Performance for Pharmaceutical Applications
• Ideal selectivity for simultaneous separation of Active Pharmaceutical Ingredients (API) and counterions (basic, neutral and acidic analytes)
• Effective retention of hydrophilic ionic and ionizable analytes without ion-pairing reagents
• Distinctive spatial separation of the anion-exchange and cation-exchange regions
• Flexible method development with each retention mechanism controlled independently
• Low column bleed; compatible with mass spectrometry (MS), charged aerosol detection (CAD) and evaporative light scattering detectors (ELSD)
• Available in 2.1 and 3 mm diameters and 50, 100 and 150 mm lengths

Complement the Acclaim Trinity P1 column with the Acclaim Trinity P2 column to provide a total solution for pharmaceutical counterion analysis by HPLC. Use the Acclaim Trinity P2 column to separate counterions, including monovalent and divalent cations or anions.

About the Family of Acclaim Specialty HPLC Columns
Acclaim specialty columns have been developed, manufactured and tested to meet the separation needs of specific applications. These columns are based on novel and unique chemistries and provide superior resolution with ease of use.

• Use tested to guarantee consistent separations
• Ideal selectivity for separating specific target analytes
• Excellent peak shapes
• Performance tested to ensure high quality and reliability for specific chromatographic separations
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