Description
GenScript Benz-Neburase™ Nuclease ELISA Kit is a sensitive assay to detect and quantify residual endonuclease impurity in purification and manufacturing processes of viral vectors and vaccines where utilized Benz-Neburase™ Nuclease or other Serratia marcescens endonucleases. Benz-Neburase™ Nuclease ELISA Kit is based on sandwich ELISA with a detection limit of 8.40 pg/ml. It is a simple, accurate and reproducible solution for residual endonuclease quantitation to add to the purification process, quality control, and release testing. Benz-NeburaseTM Nuclease is genetically engineered endonuclease from S. marcescens that cleaves all forms of DNA and RNA non-specifically, including single stranded, double stranded, linear and circular. They are mostly used to remove residual nucleic acids during production process of biological molecules in biopharmaceutical manufacturing including but not limited to vaccine production, viral vector production, and manufacturing of gene and cell therapy-related products.