Biotinylated Recombinant Human HER1/ERBB1/EGFR (25-378) Protein

$492.80

Weight 3 lbs
Dimensions 5 × 5 × 5 in
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SKU: Abclonal-RP00500B- 100 μg Category:

Description

The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene amplification frequently contain EGFR gene rearrangements, with the most common extracellular domain mutation being EGFRvIII. This mutation leads to a deletion of exons 2-7 of the EGFR gene and renders the mutant receptor incapable of binding any known ligand.

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