Biotinylated Recombinant Human PTPRC/CD45R0/CD45 Protein

$1,760.00

Weight	3 lbs
Dimensions	5 × 5 × 5 in
Brand	ABclonal Technology
Size/Quantity	1-EA
Product Size	500 μg
Shipping Condition	Wet Ice
Manufacturer Part No	RP00395B

SKU: Abclonal-RP00395B Category: Proteins

Description

Description

PTPRC (also known as CD45),T cells require the protein tyrosine phosphatase CD45 to detect and respond to antigen because it activates the Src family kinase Lck, which phosphorylates the T cell antigen receptor (TCR) complex. CD45 ativates Lck by opposing the negative regulatory kinase Csk. Paradoxically, CD45 has also been implicated in suppressing TCR signaling by dephosphorylating the same signaling motifs within the TCR complex upon which Lck acts.

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