Description
CD96 (Cluster of Differentiation 96), also known as Tactile (T cell activation, increased late expression), is a receptor protein which is expressed on T cells and NK cells and shares sequence similarity with CD226 (also known as DNAM-1). The main ligand of CD96 is CD155 and CD96 competes with CD226 for binding to CD155. This protein belongs to the immunoglobulin superfamily and may play a role in the adhesive interactions of activated T and NK cells during the late phase of the immune response. It may also promote NK cell-target adhesion by interacting with PVR present on target cells and function in antigen presentation.