Description
Clozapine is a dibenzodiazepine compound, structurally related to loxapine is used in cell signaling research. It is an a typical antipsychotic medication used in the treatment of schizophrenia. It is a dopamine D4 and D2 receptor antagonist which has high affinity for the cloned rat dopamine D4 receptor (Ki < 20 nM). It is also a potent, selective muscarinic antagonist which exhibits the highest reported affinity for 5-HT1A and 5-HT1C sites.