Ikaros Rabbit mAb

$113.96

Weight 3 lbs
Dimensions 5 × 5 × 5 in
Brand

Size/Quantity

Product Size

Shipping Condition

Manufacturer Part No

SKU: Abclonal-A3565 Category:

Description

This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL).

Please Submit Your Inquiries Below
Name(Required)
This field is for validation purposes and should be left unchanged.

What Makes Us Unique?

The Adva Tech portfolio offers a comprehensive workflow for your manufacturing needs with wide range of services that includes on site Inventory Management, Procurement Management, and Manufacturing Capabilities such as custom pack and private labeling.

Every client in the life science reagents and chemicals industry has unique needs and deserve unique solutions.

By partnering with the Adva Tech team, you will be supported throughout the life cycle of your product. This collaboration results in building better products, increasing efficiencies, and reducing cost & waste.

Adva Tech team is committed to your success and ready to help your company meet and exceed expectations.

Learn More