[KD Validated] PKA C-alpha (PRKACA) Mouse mAb

$113.96

Weight 3 lbs
Dimensions 5 × 5 × 5 in
Brand

Size/Quantity

Product Size

Shipping Condition

Manufacturer Part No

SKU: Abclonal-A21869- 20 μL Category:

Description

This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing’s syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. Tissue-specific isoforms that differ at the N-terminus have been described, and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms.

Please Submit Your Inquiries Below
Name(Required)
This field is for validation purposes and should be left unchanged.

What Makes Us Unique?

Adva Tech Group, Inc. is a distributor of Life Science Reagents and Chemicals. Our customer base includes industries such as Advanced Technologies, Biologicals, Clinical, Controlled Environments and Cleanroom Solutions, Education, Environmental, Federal Government, Forensics, Food and Beverage, Industrial, Molecular Diagnostics, Petrochemical, Pharmaceuticals and Biotechnology, State and Local Government.

As a newly established supplier of chemicals and equipment, we offer a comprehensive supply of chemistry & laboratory equipment, designed to meet the rigorous demands of your research, experiments, and manufacturing needs. Our inventory offers everything from basic to advanced chemicals and equipment, ensuring that whether you are conducting complex chemical manufacturing or routine testing, you have access to top-quality chemistry & lab supplies.

Learn More