[KD Validated] Thymidylate synthase Rabbit mAb

$94.99

application (WB, IHC-P, ELISA) & cross reactivity (Human)

Weight	1.00 lbs
Dimensions	5.00 × 5.00 × 5.00 in
Manufacturer	ABclonal Technology
Size/Quantity	1-EA
Product Size	20ul
Manufacturer Part No	A24168
Ship to Residential	NO

SKU: Abclonal-A24168-20ul

SKU: Abclonal-A24168-20ul Category: Antibodies Brand: ABclonal Technology

Description

Description

Size quantity : 1-EA
Description : Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy.

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