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[KO Validated] PHD2/EGLN1 Rabbit pAb

[KO Validated] PHD2/EGLN1 Rabbit pAb

$103.04

Polyclonal Antibodies

Weight 3 lbs
Dimensions 5 × 5 × 5 in
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SKU: Abclonal-A14557-20μL
SKU: Abclonal-A14557-20μL Category:

Description

The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3).

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