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Nectin-2/CD112 Fc Chimera, Human

$103.50

Nectin-2, also known as CD112 (Cluster of Differentiation 226) and PVRL2 (Poliovirus receptor-related 2), is a human plasma membrane glycoprotein. This protein is a modulator of T-cell signaling and can be either a costimulator of T-cell function or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, it stimulates T-cell proliferation and cytokine production, including that of IL-2, IL-5, IL-10, IL-13, and IFNγ. It can also inhibit T-cell proliferation upon interaction with PVRIG. Nectin-2 also acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV).

Weight 1.00 lbs
Dimensions 5 × 5 × 5 in
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SKU: GSB-Z03456-50 Category: Brand:

Description

Nectin-2, also known as CD112 (Cluster of Differentiation 226) and PVRL2 (Poliovirus receptor-related 2), is a human plasma membrane glycoprotein. This protein is a modulator of T-cell signaling and can be either a costimulator of T-cell function or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, it stimulates T-cell proliferation and cytokine production, including that of IL-2, IL-5, IL-10, IL-13, and IFNγ. It can also inhibit T-cell proliferation upon interaction with PVRIG. Nectin-2 also acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV).

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