Description
Leukocyte-associated immunoglobulin-like receptor 2 ( LAIR2 ), also known as CD36, is a 131 amino acid protein containing one lg-like C2-type domain, making it a member of the Ig superfamily. When compared to LAIR-1, its transmembrane counterpart, it shares 83% aa identity across the signal sequence and extracellular domains, the two LAIR proteins are thought to have arisen from a common gene ancestor and appear to share similar adhesion profiles. LAIR2 is thought to be secreted and may help modulate mucosal tolerance. As a natural competitor for LAIR1, soluble LAIR2 prevents binding of human LAIR1 to collagens and LAIR1 cross-linking, thereby regulating its inhibitory potential. LAIR2 is thought to be secreted and may help modulate mucosal tolerance.