Recombinant Human LGR5 / GPR49 protein

$644.00

Proteins

Weight	3 lbs
Dimensions	5 × 5 × 5 in
Manufacturer	ABclonal Technology
Size/Quantity	1-EA
Product Size	100 µg
Shipping Condition	Wet Ice
Manufacturer Part No	RP03501-100μg

SKU: Abclonal-RP03501-100μg

Description

Description

LGR5 (also known as GPR49) is a seven-transmembrane protein of the class A Rhodopsin-like family of GPCRs. LGR5 and LGR4 bind the R-spondins with high affinity and mediate the potentiation of Wnt/β-catenin signaling by enhancing Wnt-induced LRP6 phosphorylation. The LGR5/RSPO complex could promote Wnt signalling via the neutralization of two transmembrane E3 ligases, RNF43 and ZNRF3.

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