Description
FGF-6 is a member of the large and diverse fibroblast growth factor (FGF) family of peptide growth factors. FGF-6 binds to receptor FGFR4 and functions as a signaling molecule that is involved in many important processes . The mouse homolog of this gene exhibits predominantly in the myogenic lineage which suggests a role in muscle regeneration or differentiation . FGF-6 was able to transform NIH/3T3 cells and the resulting transformant formed a well-vascularized tumor in nude mice, thus suggesting an angiogenic property similar to some other members of the FGF family .