Description
Spectra/Por® In Vivo Microdialysis Hollow Fibers were developed for applications requiring in vivo recovery or dispensing of microquantities of biological materials within a localized section of a functioning organ of animals. This concept is an artificial blood vessel implanted within the tissue, to recover substances from or add to the organ. Animal metabolic experiments can be carried out by using radioisotope techniques in combination with analytical chemistry. There will be internal molecular or ionic permeation through the membrane and the tissue. This entire biological test can be conducted with less than a cubic millimeter of tissue.
The In Vivo Microdialysis Hollow Fibers are filled with a water-insoluble, alcohol-soluble liquid to keep the fibers open. This is to prevent fiber deformation during subsequent handling and to maintain the circular shape of the fibers during assembly of the hollow fiber devices. The filling liquid, called isopropyl myristate (IM), is removed with a small amount of ethyl alcohol. It should be noted that cellulose will not swell under the influence of ethyl alcohol.
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