TRIS AMINO AC Ultra Pure, USP, EP, Biologics Grade
Manufactured by ANGUS Chemical Company, TRIS AMINO™ AC (Advanced Crystal) Ultra Pure buffer features a unique crystal morphology that results in less time, energy and cost to break up clumps prior to buffer preparation.

TRIS AMINO AC Ultra Pure is manufactured using a proprietary process technology that produces a larger, more rounded particle. Without making any changes to the molecule itself, this process helps prevent the formation of strong, hard cakes even when subjected to a variety of packaging, shipping and storage conditions.

• Low interparticle cohesion between crystals requires less energy to break up clumps
• More spherical crystals for easy dispensing and transport
• Fewer fine particles for lower dust emissions
• No additives or anti-clumping agents
• Highest purity and testing requirements including bioburden and endotoxin
• cGMP-compliant with comprehensive documentation
• Proven safe use in commercial drug products
• Fully traceable supply chain including base materials
• Elemental impurity risk assessment using ICP-MS technology
• Ability to maintain pH from 7 to 9 by utilizing a combination of free base and its salts
• Amine and alcohol functionality for versatile chemical reactivity

Uses and Applications
• Pharmaceutical raw material compliant with USP, EP, JPC, and ChP monographs
• Commercial purification (downstream processing) of biological molecules including monoclonal antibodies and recombinant proteins
• Processing aid for insulin manufacturing
• Non-sterile pharmaceutical excipient
• Buffer for molecular biology and clinical diagnostic applications
• pH buffering of enzymes in biotechnology applications
• Small molecule API salt to systematically adjust drug hydrophilicity
• Small molecule synthesis building block

Typical Properties*
Purity: 99.9%
Molecular weight: 121.14
Melting point: 168.0 – 172.0°C
pKa @ 20°C: 8.3
pKa @ 37°C: 7.8
pKa/°C: -0.03
pH of 0.1M aqueous solution (20°C): 10.4
Ä pH/10X dilution: -0.05 to -0.10

*Values shown are typical properties and are not to be considered product specifications. Biologics Grade is tested for bioburden and endotoxin.