Ambient

Molecular Formula : C29 H44 O12

Molecular Formula : C29 H44 O12 . 8 H2 O

Molecular Formula : C29H41D3O12

Molecular Formula : C29H41D3O12

Outlet Tubing 0.5 – 2.5M Dispenser

OX40 (TNFRSF4, CD134) is a member of the tumor necrosis factor (TNF) receptor superfamily that regulates T cell activity and immune responses. The OX40 protein contains four cysteine rich domains, a transmembrane domain, and a cytoplasmic tail containing a QEE motif. OX40 is primarily expressed on activated CD4+ and CD8+ T-cells, while the OX40 ligand (OX40L, TNFSF4, CD252) is predominantly expressed on activated antigen presenting cells. The engagement of OX40 with OX40L leads to the recruitment of TNF receptor-associated factors (TRAFs) and results in the formation of a TCR-independent signaling complex. One component of this complex, PKCθ, activates the NF-κB pathway. OX40 signaling through Akt can also enhance TCR signaling directly. Research studies indicate that the OX40L-OX40 pathway is associated with inflammation and autoimmune diseases. Additional research studies show that OX40 agonists augment anti-tumor immunity in several cancer types.

OX40 (TNFRSF4, CD134) is a member of the tumor necrosis factor (TNF) receptor superfamily that regulates T cell activity and immune responses. The OX40 protein contains four cysteine rich domains, a transmembrane domain, and a cytoplasmic tail containing a QEE motif. OX40 is primarily expressed on activated CD4+ and CD8+ T-cells, while the OX40 ligand (OX40L, TNFSF4, CD252) is predominantly expressed on activated antigen presenting cells. The engagement of OX40 with OX40L leads to the recruitment of TNF receptor-associated factors (TRAFs) and results in the formation of a TCR-independent signaling complex. One component of this complex, PKCθ, activates the NF-κB pathway. OX40 signaling through Akt can also enhance TCR signaling directly. Research studies indicate that the OX40L-OX40 pathway is associated with inflammation and autoimmune diseases. Additional research studies show that OX40 agonists augment anti-tumor immunity in several cancer types.

OX40 is a T cell co-stimulatory molecule of the TNF receptor superfamily that coordinates with other co-stimulators (CD28, CD40, CD30, CD27 and 4-1BB) to manage the activation of the immune response. Tumor necrosis factor ligand superfamily member 4 (TNFSF4) is also known as glycoprotein Gp34, OX40 ligand (OX40L), TAX transcriptionally-activated glycoprotein 1 and CD252, which belongs to the tumor necrosis factor family. TNFSF4 is the ligand for CD134 and is expressed on cells such as DC2s (a subtype of dendritic cells) enabling amplification of Th2 cell differentiation. OX40 is constitutively expressed on Tregs and enhances the sensitivity of Tregs to IL-2, thus promoting Treg proliferation. OX40 has also shown to decrease the cells’ immunosuppressive activity on effector T cells. OX40-OX40 Ligand signaling is involved in allergic airway inflammation, graft-versus-host disease and autoimmune disease.

OX40 is a T cell co-stimulatory molecule of the TNF receptor superfamily that coordinates with other co-stimulators (CD28, CD40, CD30, CD27 and 4-1BB) to manage the activation of the immune response. Tumor necrosis factor ligand superfamily member 4 (TNFSF4) is also known as glycoprotein Gp34, OX40 ligand (OX40L), TAX transcriptionally-activated glycoprotein 1 and CD252, which belongs to the tumor necrosis factor family. TNFSF4 is the ligand for CD134 and is expressed on cells such as DC2s (a subtype of dendritic cells) enabling amplification of Th2 cell differentiation. OX40 is constitutively expressed on Tregs and enhances the sensitivity of Tregs to IL-2, thus promoting Treg proliferation. OX40 has also shown to decrease the cells’ immunosuppressive activity on effector T cells. OX40-OX40 Ligand signaling is involved in allergic airway inflammation, graft-versus-host disease and autoimmune disease.

Tumor necrosis factor ligand superfamily member 4 (TNFSF4) is also known as glycoprotein Gp34, OX40 ligand (OX40L), which belongs to the tumor necrosis factor family. It is expressed on such cells as DC2s (a subtype of dendritic cells) enabling amplification of Th2 cell differentiation.

Molecular Formula : C19 H17 N3 O5 S . 2 Na

Molecular Formula : C19 H17 N3 O5 S . 2 Na

Molecular Formula : C19 H19 N3 O5 S . Na . x[H2O]

Molecular Formula : C19 H19 N3 O5 S . Na . x[H2O]

Molecular Formula : C19 H19 N3 O5 S . Na . x[H2O]

Molecular Formula : C19 D5 H13 N3 O5 S . Na

Molecular Formula : C19 D5 H13 N3 O5 S . Na

Molecular Formula : C19 D5 H13 N3 O5 S . Na

CAS Number: 1173-88-2

CAS Number: 1173-88-2

Molecular Formula : C15 H14 Cl2 N2 O3

Molecular Formula : C15 H18 Cl2 N2 O3

Molecular Formula : C15 H18 Cl2 N2 O3

Molecular Formula : C15 H18 Cl2 N2 O3

Oxalacetic Acid

Oxalacetic Acid

Oxalacetic Acid

Oxalacetic Acid

Molecular Formula : C2 H2 O4

Molecular Formula : C2 H2 O4

Molecular Formula : C2 H2 O4

Molecular Formula : C22 H24 N2 O9 . 2 H2 O

Molecular Formula : C22 H24 N2 O9 . 2 H2 O

Molecular Formula : C22 H24 N2 O9 . 2 H2 O

Oxalic Acid Dihydrate

Oxalic Acid Dihydrate

Oxalic Acid Dihydrate

Molecular Formula : C4H6O4

Molecular Formula : C4H6O4

Molecular Formula : 13C2H2O4

Molecular Formula : 13C2H2O4

Molecular Formula : 13C2H2O4

Oxalic Acid, 10 Percent (w/v) Aqueous Solution

Oxalic Acid, 10 Percent (w/v) Aqueous Solution

Oxalic Acid, 10 Percent (w/v) Aqueous Solution