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Molecular Formula : C7H2D5ClNa2O6P2S

Molecular Formula : C7H2D5ClNa2O6P2S

T cell Ig- and mucin-domain-containing molecules (TIMs) are a family of transmembrane proteins expressed by various immune cells. TIM-3 is an inhibitory molecule that is induced following T cell activation. TIM-3 is expressed by exhausted T cells in the settings of chronic infection and cancer, and tumor-infiltrating T cells that co-express PD-1 and TIM-3 exhibit the most severe exhausted phenotype. Tumor-infiltrating dendritic cells also express TIM-3. TIM-3 expression on DCs was found to suppress innate immunity by reducing the immunogenicity of nucleic acids released by dying tumor cells. Research studies show that heterodimerization of TIM-3 with CEACAM-1 is critical for the inhibitory function of TIM-3, and co-blockade of TIM-3 and CEACAM-1 enhanced antitumor responses in a mouse model of colorectal cancer. Its binding to Galectin-9 induces a range of immunosuppressive functions which enhance immune tolerance and inhibit anti-tumor immunity. TIM-3 ligation attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. In addition, dendritic cell-expressed TIM-3 dampens inflammation by enabling the phagocytosis of apoptotic cells and the cross-presentation of apoptotic cell antigens.

T cell Ig- and mucin-domain-containing molecules (TIMs) are a family of transmembrane proteins expressed by various immune cells. TIM-3 is an inhibitory molecule that is induced following T cell activation. TIM-3 is expressed by exhausted T cells in the settings of chronic infection and cancer, and tumor-infiltrating T cells that co-express PD-1 and TIM-3 exhibit the most severe exhausted phenotype. Tumor-infiltrating dendritic cells also express TIM-3. TIM-3 expression on DCs was found to suppress innate immunity by reducing the immunogenicity of nucleic acids released by dying tumor cells. Research studies show that heterodimerization of TIM-3 with CEACAM-1 is critical for the inhibitory function of TIM-3, and co-blockade of TIM-3 and CEACAM-1 enhanced antitumor responses in a mouse model of colorectal cancer. Its binding to Galectin-9 induces a range of immunosuppressive functions which enhance immune tolerance and inhibit anti-tumor immunity. TIM-3 ligation attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. In addition, dendritic cell-expressed TIM-3 dampens inflammation by enabling the phagocytosis of apoptotic cells and the cross-presentation of apoptotic cell antigens.

User-friendly timer that displays three different countdown/alarm times simultaneously.

Molecular Formula : C22 H24 F N3 O S

Molecular Formula : C22 H24 F N3 O S

Molecular Formula : C22 H24 F N3 O S

Molecular Formula : C22H20D4FN3OS

Molecular Formula : C22H20D4FN3OS

Molecular Formula : C13 H24 N4 O3 S . C4 H4 O4

Molecular Formula : C13 H24 N4 O3 S . C4 H4 O4

Molecular Formula : C13 H24 N4 O3 S . C4 H4 O4

Timolol Maleate

Timolol Maleate, USP

Timolol Maleate, USP

Timolol Maleate, USP

Timolol Maleate, USP

Timolol Maleate, USP

Molecular Formula : C4 H7 N O2 S

Molecular Formula : C4 H7 N O2 S

Molecular Formula : C4 H7 N O2 S

Molecular Formula : C4 D4 H3 N O2 S

Molecular Formula : C4 D4 H3 N O2 S

Molecular Formula : C4 D4 H3 N O2 S

Molecular Formula : SnCl2

Tin Metal

Tin Metal

Tin Metal

Tin Metal

Tin Metal, 20 Mesh, Granular, Reagent, ACS

Tin Metal, 20 Mesh, Granular, Reagent, ACS

Tin Metal, 20 Mesh, Granular, Reagent, ACS

Tin Metal, 20 Mesh, Granular, Reagent, ACS

Tin Metal, 20 Mesh, Granular, Reagent, ACS

Tin Metal, 20 Mesh, Granular, Reagent, ACS

Tin(II) 2-Ethylhexanoate

Tin(II) 2-Ethylhexanoate

Molecular Formula : C4 H6 O4 Sn

Molecular Formula : Cl2 Sn . 2 H2 O

Molecular Formula : Cl2 Sn . 2 H2 O

Molecular Formula : Cl2 Sn . 2 H2 O

Molecular Formula : C2O4Sn

Molecular Formula : O7P2Sn2

Molecular Formula : O7P2Sn2

Molecular Formula : O7P2Sn2

Molecular Formula : C21 H25 N7 O

Molecular Formula : C21 H25 N7 O