2

T cell immunoglobulin mucin-3 (TIM-3) is a member of the T-cell Immunoglobulin- and Mucin-domain-containing family of type I membrane glycoproteins that regulate autoimmune and allergic disease. TIM-3 is selectively expressed on Th1 cells and interacts with galectin-9. It negatively regulates Th1 responses and affects macrophage activation. The 280 amino acid mature human TIM-3 contains a V-type Ig-like domain that shows multiple polymorphisms, followed by a mucin-like domain in the 171 amino acid extracellular region, which shares 60% amino acid identity with mouse TIM-3 ECD.

Thyrtropin-releasing hormone receptor1 (TRH1) is a member of G-protein coupled receptor family A. This protein is a receptor for Thyrtropin-releasing hormone (TRH). Human TRH1 is expressed in lymphocytes, pituitary gland and CNS. It can stimulate the releasing of prolactin (PRL), thyrotropin (TSH). TRH1 receptor knockout mice exhibit a slightly reduced growth rate, considerable decrease in serum T₃, T₄, and prolactin levels but no alteration of thyroid-stimulating hormone levels.

The Urotensin II receptor (UT2), also named UTS2R, GPR14, which is expressed in endothelium, smooth muscle, heart and pancreas. Pharmacological inhibition of urotensin II receptor interactions prevents renal insufficiency following renal artery ligation. .

The antidiuretic hormone arginine vasopressin (AVP) receptors are G protein-coupled receptors which consists of at least three types: V1A (vascular/hepatic) and V1B (anterior pituitary) receptors, which act through phosphatidylinositol hydrolysis to mobilize intracellular Ca²⁺; and V2 (kidney) receptor, which is coupled to adenylate cyclase. V1B receptors are expressed in anterior pituitary where they mediate the release of ACTH . Its peripheral actions, such as antidiuresis, contraction of vascular smooth muscle, and stimulation of hepatic glycogenolysis are well characterized.

Arginine vasopressin (AVP) is a cyclic nonapeptide that acts by binding to a family of vasopressin receptors that includes V1a, V1b, and V2 receptors. In particular, V2 receptors are expressed in kidney where vasopressin exerts its antidiuretic action. V1a and V1b couple to Gq and calcium release, whereas V2 couples to Gs. Mutations in V2 result in X-linked nephrogenic diabetes insipidus, a syndrome in which the kidney is unable to concentrate urine, leading to dehydration and hypernatremia. Conversely, elevated levels of AVP lead to hyponatremia in the syndrome of inappropriate antidiuretic hormone secretion (SIADH), congestive heart failure or cirrhosis, and V2 selective antagonists have been developed to treat these conditions.

Recombinant CHO-K1 cells stably overexpress V-domain Ig suppressor of T cell activation (VISTA) on the cell surface. The surface expression of VISTA is validated by FACS analysis. This cell line is designed for cell-based binding for screening antibodies binding with VISTA and evaluating target binding affinity.

The widespread neuropeptide vasoactive intestinal peptide (VIP) has two receptors VPAC1 and VPAC2. The vasoactive intestinal polypeptide receptor VPAC1 is G_s-coupled GPCRs expressed in the lung, prostate, peripheral blood leukocytes, liver, brain, small intestine colon, heart, spleen, placenta, kidney, thymus, and testis.

The Vasoactive intestinal polypeptide receptor 2 (VPAC2) is a Gs-coupled receptor expressed in the stroma of uterus and prostate; smooth muscles in gastrointestinal tract, seminal vesicles and skin; blood vessels; thymus. VPAC2 is an essential regulator of the circadian pacemaker of the hypothalamic suprachiasmatic nuclei.

Molecular Formula : 13C C23 H40 O5

Molecular Formula : C5HD13ClNO

Molecular Formula : C8 D6 H3 N O2

Molecular Formula : C8H15N

Molecular Formula : C31 H46 O2

ClickSeal Biocontainment Lids for M10 Microplate Buckets

Clinical Rotor Package includes 487-10106, 487-10109, 487-10112, 487-10133 and 487-10130

Clorox Healthcare Bleach Germicidal Wipes, Refill, Terminal Cleaning, 12 x 12 in., 110 wipes/bag

Clorox Healthcare Hydrogen Peroxide Cleaner Disinfectant Wipes Refill, 185 wipes/bag

Clorox Healthcare Hydrogen Peroxide Cleaner Disinfectant Wipes, 185 wipes/canister

Clorox(R) Healthcare VersaSure(R) Cleaner Disinfectant Wipes, 12 x 12, 110/pk, 2 pk/cs

Clorox(R) Healthcare VersaSure(R) Cleaner Disinfectant Wipes, Tub, 2 tub/cs

Molecular Formula : ((C3 H5 Cl O)mon(C4 H13 N3)mon)co . Cl H

Color-Smart Acid Gas Carbon Filters (2 each)

Color-Smart Ammonia Carbon Filters (2 each)

Color-Smart Formaldehyde Carbon Filters (2 each)

Color-Smart HEPA Filter (2 each), 3 ft./6 ft.

Color-Smart Organic Carbon Filters (2 each)

Complement C3 polyclonal antibody

Control Company Traceable Replacement Printing Paper Rolls

Corning 50 mL Polypropylene Centrifuge Tube, Self-Standing, with Dip Tube, Sterile, 1 per bag, 2 per case

Corning CellSTACK 10-Chamber Tissue Culture Treated Polystyrene Culture Chamber, 6360 cm2, Sterile

Corning CellSTACK 5-Chamber CellBIND Polystyrene Culture Chamber, 3180 cm2, Sterile

Corning HYPERStack 36-Layer Cell Culture Vessel, Corning CellBIND Surface, Sterile

Corning HYPERStack 36-Layer Cell Culture Vessel, Non-treated, Sterile

Cryogenic / Vaccine Vial Grippers, Blue, pk2

Cryogenic Vial Rack, Polypropylene, Holds 50 Vials (tray not included)

Molecular Formula : C16 H21 N O9 S

Cyclosporine, Research Grade

Molecular Formula : C6H11O9SNa