2

Angiotensin receptor 1 (AT1 receptor) is a member of angiotensin receptors which are responsible for the signal transduction of the main effecter hormone. Effects mediated by the AT1 receptor include vasoconstriction, aldosterone synthesis and secretion, increased vasopressin secretion, cardiac hypertrophy, augmentation of peripheral noradrenergic activity, vascular smooth muscle cells proliferation, decreased renal blood flow, renal renin inhibition, renal tubular sodium reuptake, modulation of central sympathetic nervous system activity, cardiac contractility, central osmocontrol and extracellular matrix formation.

Claudins are a family of proteins, which play a role in maintaining tight cell junctions. Differentclaudin subtypes are expressed on different tissues.Claudin18 isoform 2 (CLDN18.2) expressionin normal tissues is restricted to cells of the gastric mucosa and is absent from other healthytissues However, CLDN 18.2 is expressed in 70% of primary gastric adenocarcinomas and itsmetastases (101). It has also beenshown to be expressed in a number of other cancers,including pancreatic (50%), esophagus (30%) and NSCLC (25%)The restricted expressionmakes it a potential drug target for the treatment of gastric and pancreatic adenocarcinoma, asevidenced by effortsto target CLDN18.2 via naked antibody and CAR-T modalities.

* The mycoplasma test was
performed with MycoAlert™ PLUS Mycoplasma Detection Kit of Lonza.

Prostaglandins are known to affect the nervous system and can modulate synaptic transmission and neurotransmitter release, the sleep/wake cycle, fever, pain, and the immune system. Prostaglandin E2 receptor, EP1 subtype (EP1/PTGER1) is a receptor for prostaglandin E2 (PGE2). The members of the EP receptor family, EP1, EP2, EP3, and EP4, elicit their actions by altering cyclic adenosine monophosphate (cAMP) or intracellular calcium concentrations. EP1 activates phospholipase C and phosphatidylinositol turnover and stimulates the release of intracellular calcium via a Gi/Gq-coupled mechanism. EP2 and EP4 both signal through a Gs-coupled mechanism that stimulates adenylyl cyclase and increases intracellular levels of cAMP. EP1 appears to mediate the effects of PGE2 in promoting the formation of precancerous lesions in animal models of colon cancer. In addition, EP1 has an inhibitory effect on stress-induced aggressive and risk-taking behaviors in mice.

Prostaglandin F (2-alpha) is known as a potent luteolytic agent. It is involved in modulating intraocular pressure and smooth muscle contraction in uterus. Its effects on cells are mediated through specific interaction with the Prostanoid receptor FP, which is a 359-amino acid protein. Having 7 putative transmembrane domains, FP resembles the characteristic of G protein coupled receptors. Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor may initiate parturition in ovarian luteal cells and thereupon induce luteolysis.

Glucagon regulates blood glucose via control of hepatic glycogenolysis and gluconeogenesis and via regulation of insulin release from the β cell. Pharmacological administration of glucagon increases blood glucose in normal and diabetic subjects, and produces positive inotropic and chronotropic cardiovascular effects, relaxation of smooth muscle in the gastrointestinal tract and stimulation of growth hormone secretion. The actions of glucagon are mediated via a single adenylate cyclase-coupled glucagon receptor that also couples to the phospholipase C-inositol phosphate (PLC-IP) pathway leading to Ca²⁺ release from intracellular stores.

HEK293/Gα15 is a HEK293 cell line stably expressing the Gα15 alpha subunit protein which a Gq protein.  It is used as a host cell for transfection expression of Gs and Gi/o -coupled receptors, the constitutively expressed Gα15 protein in the cells allows many transfected receptors which normally stimulate/inhibit the cAMP pathway, to couple to Gq signal transduction and mobilize intracellular calcium.  The cell line carries the puromycin resistance gene and is resistant to puromycin

The H1 histamine receptor is expressed primarily in the lungs, vasculature, and brain. The H1 mediates the contraction of smooth muscles, neurotransmission in the central nervous system, the release of catecholamine from adrenal medulla, and increases in capillary permeability due to contraction of terminal venules. H1’s role in inflammatory responses makes its antagonist suitable for treating allergies.

Programmed death-ligand 1 (PD-L1) also known as cluster of differentiation 274 (CD274) or B7 homolog 1 (B7-H1) is a protein that in humans is encoded by the CD274 gene. The formation of the PD-1 receptor / PD-L1 or B7.1 receptor /PD-L1 ligand complex transmits an inhibitory signal which reduces the proliferation of these CD8+ T cells at the lymph nodes. PD-1 is also able to control the accumulation of foreign antigen specific T cells in the lymph nodes through apoptosis, which is further mediated by a lower regulation of the gene Bcl-2.

The thromboxane A2 (TxA2) receptor (TP) is a member of the G protein-coupled receptor (GPCR) superfamily which mediates TxA2-induced platelet aggregation and vasoconstriction. Dysregulation of TxA2 synthesis and function has been implicated in the pathogenesis of a number of disease states including myocardial ischemia, asthma, pregnancy-induced hypertension, and a variety of kidney diseases. TP receptors (Thromboxane A2 receptors) are widely distributed among different organ systems and localized on both cell membranes and in intracellular structures. Two isoforms of human TPs have been cloned from placenta (TPα) and endothelium (TPβ) that differ in their mechanisms and kinetics of desensitization and internalization. The TPs are linked via the Gq/G11 class of G proteins to phospholipase C (PLC), which hydrolyzes phosphoinositides to two potent second messengers: inositol 1,4,5-trisphosphate, which leads to an increase in cytoplasmic free calcium, and diacylglycerol (DAG), which activates protein kinase C (PKC).

Recombinant HEK293T cells stably overexpress human SARS-CoV-2 spike protein on their surface. The surface expression of SARS-CoV-2 spike protein is validated by FACS analysis. This stable cell line product is designed for screening antibodies against SARS-CoV-2 spike protein, as well as for measuring binding affinity and stability of antibody based biologics that bind with spike protein. GenScript also offers spike protein expressing CHO-K1 stable cell line (Cat. No. M00803) for SARS-CoV-2 study.

Hemetically Sealed Buckets for use with Z326-100H Inserts

Molecular Formula : C56 H91 O56 S7 . 7 Na

Hermetically Sealed Lids for Round Bucket Z327-200-BUK, 2/pk

Hermle PCR Stacking Adapter for Z446-750-MP ONLY (Cat. No. 485-10319)

Molecular Formula : C6H10D2O2

Molecular Formula : C8 H6 O3

Lyophilized goat antibody to rat IgG (whole molecule)

Product is horseradish peroxidase (HRP)-conjugated goat affinity purified antibody to rabbit IgG F(ab’)2 and buffer salts.

Lyophilized horseradish peroxidase (HRP)-conjugated rabbit affinity purified antibody to goat IgG (whole molecule) and buffer salts

Lyophilized horseradish peroxidase (HRP)-conjugated goat IgG fraction to dog IgG (whole molecule) and buffer salts.

Lyophilized horseradish peroxidase (HRP)-conjugated goat IgG fraction to guinea pig IgG (whole molecule) and buffer salts.

Lyophilized horseradish peroxidase (HRP)-conjugated goat IgG fraction to human albumin and buffer salts.

Lyophilized powder of horseradish peroxidase (HRP)-conjugated goat IgG fraction to human complement C3 and buffer salts.

Lyophilized horseradish peroxidase (HRP)-conjugated goat IgG fraction to human IgG Fc and buffer salts.

Lyophilized horseradish peroxidase (HRP)-conjugated goat IgG fraction to human Kappa Chain (bound) and buffer salts.

Lyophilized horseradish peroxidase (HRP)-conjugated goat IgG fraction to mouse complement C3 and buffer salts.

Lyophilized horseradish peroxidase (HRP)-conjugated goat IgG fraction to mouse IgG (whole molecule) with buffer salts.

Lyophilized horseradish peroxidase (HRP)-conjugated goat IgG fraction to mouse IgG F(ab’)2 and buffer salts.

Lyophilized horseradish peroxidase (HRP)-conjugated goat IgG fraction to mouse IgG Fc and buffer salts.

Lyophilized horseradish peroxidase (HRP)-conjugated goat IgG fraction to rabbit IgG (whole molecule) and buffer salts. IgG fraction of antiserum is essentially free of other goat serum proteins.

Lyophilized horseradish peroxidase (HRP)-conjugated goat IgG fraction to rabbit IgG F(ab’)2 and buffer salts.

Lyophilized horseradish peroxidase (HRP)-conjugated goat IgG fraction to rat IgG (whole molecule) and buffer salts.

Lyophilized horseradish peroxidase (HRP)-conjugated rabbit IgG fraction to bovine albumin and buffer salts.

Product is a conjugate of Protein A and highly purified (Rz >3.0) horseradish peroxidase. This product is a conjugate of Protein A and highly purified (Rz >3.0) horseradish peroxidase.
Protein A is a component of the cell wall of Staphylococcus aureus (Cowan 1 Strain), and binds to the Fc portion of immunoglobulin molecules of most mammalian species. It is composed of a single polypeptide chain of molecular weight 42,000. Protein A binds IgG molecules and, in some cases, IgM and IgA.

Hubbel, Mendel & Wakeman Salt Mixture

Hyaluronidase

Hydrochloric Acid, Ultratrace

Hydrofluoric Acid, Ultratrace

Molecular Formula : C17H19NO6S

Molecular Formula : C15H12F3N3O2

Molecular Formula : C2 H6 N2 O2

Molecular Formula : C18H22D6N4O8

Hypercarb 3 um, 3 x 10 mm Guard Cartridge

Hypercarb 5 um, 2.1 x 10 mm Guard Cartridge

At least 23 different variants of IFN-alpha are known. The individual proteins have molecular masses between 19-26 kDa and consist of proteins with lengths of 156-166 and 172 amino acids. All IFN-alpha subtypes possess a common conserved sequence region between amino acid positions 115-151 while the amino-terminal ends are variable. Many IFN-alpha subtypes differ in their sequences at only one or two positions. Naturally occurring variants also include proteins truncated by 10 amino acids at the carboxy-terminal end.