100g

Nitrilotriacetic Acid, CP

Nonadecane

Nonanoic Acid

Nortriptyline Hydrochloride, USP

Noscapine Hydrochloride

o-Cresolphthalein

o-Dianisidine

O-Methylhydroxylamine Hydrochloride

o-Nitrophenol

o-Phenylenediamine Dihydrochloride

O-Phosphorylethanolamine

o-Phthalaldehyde, [for HPLC Labeling]

o-Phthalaldehyde, Reagent

o-Tolidine Dihydrochloride, Reagent, ACS

o-Tolidine, Powder, Reagent

o-Tolualdehyde, Stabilized with 0.1 Percent Hydroquinone

o-Toluic Acid

o-Toluidine Hydrochloride

o-Toluoyl Chloride

o-Vanillin

O,O’-Diethyl Dithiophosphate, 85+ Percent

Octadecyltrichlorosilane

Octyl Acetate

Octyl-beta-D-glucopyranoside

Omeprazole, USP

Orange G

Orange II

Orange IV

Orcein, Synthetic

Orotic Acid Sodium Salt

Orotic Acid, Monohydrate

Orphenadrine Citrate, USP

OX40 (TNFRSF4, CD134) is a member of the tumor necrosis factor (TNF) receptor superfamily that regulates T cell activity and immune responses. The OX40 protein contains four cysteine rich domains, a transmembrane domain, and a cytoplasmic tail containing a QEE motif. OX40 is primarily expressed on activated CD4+ and CD8+ T-cells, while the OX40 ligand (OX40L, TNFSF4, CD252) is predominantly expressed on activated antigen presenting cells. The engagement of OX40 with OX40L leads to the recruitment of TNF receptor-associated factors (TRAFs) and results in the formation of a TCR-independent signaling complex. One component of this complex, PKCθ, activates the NF-κB pathway. OX40 signaling through Akt can also enhance TCR signaling directly. Research studies indicate that the OX40L-OX40 pathway is associated with inflammation and autoimmune diseases. Additional research studies show that OX40 agonists augment anti-tumor immunity in several cancer types.

OX40 is a T cell co-stimulatory molecule of the TNF receptor superfamily that coordinates with other co-stimulators (CD28, CD40, CD30, CD27 and 4-1BB) to manage the activation of the immune response. Tumor necrosis factor ligand superfamily member 4 (TNFSF4) is also known as glycoprotein Gp34, OX40 ligand (OX40L), TAX transcriptionally-activated glycoprotein 1 and CD252, which belongs to the tumor necrosis factor family. TNFSF4 is the ligand for CD134 and is expressed on cells such as DC2s (a subtype of dendritic cells) enabling amplification of Th2 cell differentiation. OX40 is constitutively expressed on Tregs and enhances the sensitivity of Tregs to IL-2, thus promoting Treg proliferation. OX40 has also shown to decrease the cells’ immunosuppressive activity on effector T cells. OX40-OX40 Ligand signaling is involved in allergic airway inflammation, graft-versus-host disease and autoimmune disease.

Tumor necrosis factor ligand superfamily member 4 (TNFSF4) is also known as glycoprotein Gp34, OX40 ligand (OX40L), which belongs to the tumor necrosis factor family. It is expressed on such cells as DC2s (a subtype of dendritic cells) enabling amplification of Th2 cell differentiation.

Oxalacetic Acid

Oxalyl Chloride

Oxalyl Chloride, Reagent

Oxamic Acid Sodium Salt

Oxamic Hydrazide

Oxamide

Oxone(R), Monopersulfate Compound

Oxycodone Hydrochloride (CII), USP

Oxymetazoline Hydrochloride, USP

p-Acetamidobenzoic Acid

p-Aminoacetophenone

p-Aminophenol

p-Anisic Acid

p-Benzoquinone

p-Bromobenzoic Acid