1mg

Molecular Formula : C5H7D3N2O

Molecular Formula : 13C5H915NO2

Molecular Formula : C5 D3 H6 N O2

Molecular Formula : ¹³C5H7NO3

Molecular Formula : 13C5 H10 O5

Molecular Formula : C11 H20 N2 O6

Molecular Formula : C9H11N5O3

Molecular Formula : C3 D7 N O3

Molecular Formula : C19H19D4N7O6

Molecular Formula : C14 H19 N O2 . Cl H

Molecular Formula : C13H17NO2

Molecular Formula : C13H8D9NO2

Molecular Formula : C4H9¹⁵NO3

Molecular Formula : 13C11H1215N2O2

Molecular Formula : C11 D3 H9 N2 O2

Molecular Formula : C58H79N15O16 .XC2HF3O2

Molecular Formula : C9 D7 H4 N O3

Molecular Formula : C13H12D8N6O4 • xHCl

Molecular Formula : C38 H76 N O8 P

Molecular Formula : C26H23D10NO6

Molecular Formula : C13 D3 H15 N2 O3

Molecular Formula : C26 H45 N O21

Molecular Formula : C12H24ClNO10

Molecular Formula : C12 H22 O14 S

Molecular Formula : C1113CH22O11

Lymphocyte activation gene-3 (LAG-3), also known as CD223, is a cell-surface 70kDa molecule belong to Ig superfamily with diverse biologic effects on T cell function. LAG-3 is a CD4 homolog originally cloned in 1990. The gene for LAG-3 lies adjacent to the gene for CD4 on human chromosome 12 (12p13) and is approximately 20% identical to the CD4 gene. human LAG-3 shares 70%, 67%, 76%, and 73% aa sequence identity with mouse, rat, porcine, and bovine LAG-3, respectively. LAG-3 is expressed on B cells, NK cells, tumor-infiltrating lymphocytes, and a subset of T cells. LAG-3 was relatively overexpressed on transgenic T cells rendered anergic in vivo by encounter with cognate self-antigen. LAG-3 negatively regulates murine T cell activation and homeostasis. LAG-3 activates antigen-presenting cells through MHC class II signaling, leading to increased antigen-specific T-cell responses in vivo. Blocking or knocking out LAG-3 in neuronal cultures or in animals mitigated the transmission of α-synuclein between neurons, and dampened accumulation as well as toxic effects of the fibrils on motor function. Anti-LAG3 antibodies are already being tested as cancer treatments, it could also make a useful therapeutic target to treat Parkinson’s and other synucleinopathies.

Molecular Formula : C8H12N3O6PS:[C6H15N]ₓ

Molecular Formula : C8H14N3O12P3S . [C6H15N]x

Molecular Formula : C713CH9D2N3O3S

Molecular Formula : 13C C7 H11 15N2 N O3 S

Molecular Formula : C19 H14 Cl4 N10

Molecular Formula : 13C3 C6 H7 Cl2 N5

Molecular Formula : 13C3 C6 2H3 H4 Cl2 N5

Molecular Formula : C13 D5 H9 N2

Molecular Formula : C21H36N4O8

Molecular Formula : C30 H50 O

Molecular Formula : C16H10D4F3N3O4S

Molecular Formula : C29 H26 Cl F N4 O4 S . 2 C7 H8 O3 S . H2 O

Molecular Formula : C29H21D7Cl3FN4O4S

Molecular Formula : C26 H40 O5

Molecular Formula : C23 H34 O5

Molecular Formula : C23H30D4O5

Molecular Formula : C44 H82 O5 Si3

Molecular Formula : C13H20N2O4

Molecular Formula : C49 H54 F2 N8 O6

Molecular Formula : C12 D4 H5 F3 N2 O2

Molecular Formula : C13H8D5N3O3

Molecular Formula : C21H14D5ClN4O4

Leptin is a cytokine belonging to the Interleukin 6 family, and has a four-helix bundle structure. Leptin is encoded by the ob gene, and produced and secreted by white adipose tissue. The receptors of Leptin are Type I cytokine receptors, which exist in two different forms: a short form expressed in multiple tissues, and a long form expressed exclusively in the central nervous system (CNS). Upon binding to Leptin, the receptors activate the JAK/STAT3 pathway and PI3K, and stimulate transcriptional programs that regulate feeding behavior, metabolic rate, endocrine axes, and glucose fluxes. The deficiency of Leptin in human and mouse causes morbid obesity, diabetes, and neuroendocrine anomalies. Leptin also has effects on reproduction and immunity. In summary, Leptin is a pivotal cytokine controlling energy balance, and as such has profound effects on human health.

Leptin is a cytokine belonging to the Interleukin 6 family, and has a four-helix bundle structure. Leptin is encoded by the ob gene, and produced and secreted by white adipose tissue. The receptors of Leptin are Type I cytokine receptors, which exist in two different forms: a short form expressed in multiple tissues, and a long form expressed exclusively in the central nervous system (CNS). Upon binding to Leptin, the receptors activate the JAK/STAT3 pathway and PI3K, and stimulate transcriptional programs that regulate feeding behavior, metabolic rate, endocrine axes, and glucose fluxes. The deficiency of Leptin in human and mouse causes morbid obesity, diabetes, and neuroendocrine anomalies. Leptin also has effects on reproduction and immunity. In summary, Leptin is a pivotal cytokine controlling energy balance, and as such has profound effects on human health.