1mg

Molecular Formula : C22H20D6N2O4S

Molecular Formula : C15 H21 N O S

Molecular Formula : C13D6H12NNaO5S

Molecular Formula : C13 D6 H12 Cl N O2

Molecular Formula : C42 H68 N2 O2

Molecular Formula : C12H15D3ClNO2S

Molecular Formula : C20H24N2

Molecular Formula : C20 H24 N2 . C4 H4 O4

Molecular Formula : C20H24N2O • (C4H4O4)

Molecular Formula : C16H23D4ClN2O2

Molecular Formula : C34 H30 N2 O7

Molecular Formula : 13C2 H7 N . Cl H

Molecular Formula : C18 H29 N6 O9 P

Molecular Formula : C1213C2H17Cl2N315N4

Molecular Formula : C99H155N31O23 . x(C2HF3O2)

Molecular Formula : 13C6 C4 H12 N2 O5

Molecular Formula : C7 D3 H11 N4 O3

Molecular Formula : C22 H20 O12

Molecular Formula : C42 D3 H41 O24

Molecular Formula : C28 H28 O18

Molecular Formula : C22H19D3NaO12

Molecular Formula : C16 2H3 H9 O6

Molecular Formula : C14 D3 H9 O4

Molecular Formula : C23 2H4 H12 O3

Molecular Formula : C17 D3 H18 N O . HCl

Molecular Formula : C23H23D6NO7

Molecular Formula : C17H15D6NO2

Molecular Formula : C12 D10 H O4 P

Molecular Formula : C202H4H10O4

Molecular Formula : C24 H31 N O . Cl H

Molecular Formula : C26 H35 N O4 . Cl H

Molecular Formula : C26H33D3ClNO4

Molecular Formula : C12 H6 N6

Molecular Formula : C32H54N10O14

Molecular Formula : C28H47N9O9

Molecular Formula : C24H20D20N8O4

Molecular Formula : C13H13D3N3NaO4S

Molecular Formula : C21 H15 D14 N3 O • C7 H8 O3 S

Molecular Formula : C14 H17 N5 O3 S

Molecular Formula : C16 H14 N2 O4

Molecular Formula : C23 D5 H31 O5

Molecular Formula : C10 2H20 N2 S4

Molecular Formula : C14 D4 N2 O2 S2

Molecular Formula : C18H20N2O6 • 2HCl

Dickkopf related protein 1 (DKK-1) is a chemokine that belongs to the DKK protein family, which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. It is one of the most up-regulated genes during androgen-potentiated balding, with DKK-1 messenger RNA up-regulated a few hours after DHT treatment of hair follicles at the dermal papilla in vitro. Neutralizing bodies against DKK-1 reverses DHT effects on outer root sheath keratinocytes. DKK-1 expression is attenuated by L-threonate, a metabolite of ascorbate in vitro. DKK-1 promotes LRP6 internalization and degradation as it forms a ternary complex with the cell surface receptor Kremen. DKK-1 not only functions as a head inducer during development, but also regulates joint remodeling and bone formation, which indicate sits role in the pathogenesis of rheumatoid arthritis and multiple myeloma.

Dickkopf related protein 1 (DKK-1) is a chemokine that belongs to the DKK protein family, which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. It is one of the most up-regulated genes during androgen-potentiated balding, with DKK-1 messenger RNA up-regulated a few hours after DHT treatment of hair follicles at the dermal papilla in vitro. Neutralizing bodies against DKK-1 reverses DHT effects on outer root sheath keratinocytes. DKK-1 expression is attenuated by L-threonate, a metabolite of ascorbate in vitro. DKK-1 promotes LRP6 internalization and degradation as it forms a ternary complex with the cell surface receptor Kremen. DKK-1 not only functions in head formation during development, but also regulates joint remodeling and bone formation indicating its potential role in the pathogenesis of rheumatoid arthritis and multiple myeloma.

Molecular Formula : No Data Available

Molecular Formula : C613C3H13N3O5