Ambient

Molecular Formula : C27H44O3

Molecular Formula : C10H8BrNO

Molecular Formula : C10H8BrNO

Molecular Formula : C41 H71 N3 O8

Molecular Formula : C41 H71 N3 O8

Molecular Formula : C41 H71 N3 O8

Molecular Formula : C41H61D10N3O8

Molecular Formula : C41H61D10N3O8

Molecular Formula : C17 H23 N O2 . Cl H

Molecular Formula : C17 H23 N O2 . Cl H

Molecular Formula : C13 H19 N O2 . Cl H

Molecular Formula : C13 H19 N O2 . Cl H

Molecular Formula : C13 H19 N O2 . Cl H

Molecular Formula : C17 2H6 H17 N O2 . Cl H

Molecular Formula : C17 2H6 H17 N O2 . Cl H

Molecular Formula : C20H19N3O2

Molecular Formula : C20H19N3O2

Molecular Formula : C46 H80 N2 O13 . H3 O4 P

Molecular Formula : C46 H80 N2 O13 . H3 O4 P

Molecular Formula : C46 H80 N2 O13 . H3 O4 P

Molecular Formula : C46H77D3N2O13

Molecular Formula : C46H77D3N2O13

Molecular Formula : C46H77D3N2O13

Molecular Formula : C46 H80 N2 O13

Molecular Formula : C46 H80 N2 O13

Molecular Formula : C46 H80 N2 O13

Molecular Formula : C25 H34 N2 O3 . 2 Cl H

Molecular Formula : C25 H34 N2 O3 . 2 Cl H

Molecular Formula : C25 H34 N2 O3 . 2 Cl H

Molecular Formula : C7 H7 Cl O6 P2 S . 2 Na

Molecular Formula : C7 H7 Cl O6 P2 S . 2 Na

Molecular Formula : C7 H7 Cl O6 P2 S . 2 Na

Molecular Formula : C7H2D5ClNa2O6P2S

Molecular Formula : C7H2D5ClNa2O6P2S

T cell Ig- and mucin-domain-containing molecules (TIMs) are a family of transmembrane proteins expressed by various immune cells. TIM-3 is an inhibitory molecule that is induced following T cell activation. TIM-3 is expressed by exhausted T cells in the settings of chronic infection and cancer, and tumor-infiltrating T cells that co-express PD-1 and TIM-3 exhibit the most severe exhausted phenotype. Tumor-infiltrating dendritic cells also express TIM-3. TIM-3 expression on DCs was found to suppress innate immunity by reducing the immunogenicity of nucleic acids released by dying tumor cells. Research studies show that heterodimerization of TIM-3 with CEACAM-1 is critical for the inhibitory function of TIM-3, and co-blockade of TIM-3 and CEACAM-1 enhanced antitumor responses in a mouse model of colorectal cancer. Its binding to Galectin-9 induces a range of immunosuppressive functions which enhance immune tolerance and inhibit anti-tumor immunity. TIM-3 ligation attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. In addition, dendritic cell-expressed TIM-3 dampens inflammation by enabling the phagocytosis of apoptotic cells and the cross-presentation of apoptotic cell antigens.

T cell Ig- and mucin-domain-containing molecules (TIMs) are a family of transmembrane proteins expressed by various immune cells. TIM-3 is an inhibitory molecule that is induced following T cell activation. TIM-3 is expressed by exhausted T cells in the settings of chronic infection and cancer, and tumor-infiltrating T cells that co-express PD-1 and TIM-3 exhibit the most severe exhausted phenotype. Tumor-infiltrating dendritic cells also express TIM-3. TIM-3 expression on DCs was found to suppress innate immunity by reducing the immunogenicity of nucleic acids released by dying tumor cells. Research studies show that heterodimerization of TIM-3 with CEACAM-1 is critical for the inhibitory function of TIM-3, and co-blockade of TIM-3 and CEACAM-1 enhanced antitumor responses in a mouse model of colorectal cancer. Its binding to Galectin-9 induces a range of immunosuppressive functions which enhance immune tolerance and inhibit anti-tumor immunity. TIM-3 ligation attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. In addition, dendritic cell-expressed TIM-3 dampens inflammation by enabling the phagocytosis of apoptotic cells and the cross-presentation of apoptotic cell antigens.

User-friendly timer that displays three different countdown/alarm times simultaneously.

Molecular Formula : C22 H24 F N3 O S

Molecular Formula : C22 H24 F N3 O S

Molecular Formula : C22 H24 F N3 O S

Molecular Formula : C22H20D4FN3OS

Molecular Formula : C22H20D4FN3OS

Molecular Formula : C13 H24 N4 O3 S . C4 H4 O4

Molecular Formula : C13 H24 N4 O3 S . C4 H4 O4

Molecular Formula : C13 H24 N4 O3 S . C4 H4 O4

Timolol Maleate

Timolol Maleate, USP

Timolol Maleate, USP

Timolol Maleate, USP