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Tetrathionate (TT) Broth Base, Hajna, 10 kg

Tetrathionate Broth Base, 10 kg

Transforming Growth Factor-alpha (TGF-α) , also known as sarcoma growth factor, TGF-type I and ETGF, is a member of the EGF family of cytokines. It is expressed in monocytes, brain cells, keratinocytes and various tumor cells. TGF-α signals through EGFR and acts synergistically with TGF-beta to promote the proliferation of a wide range of epidermal and epithelial cells. TGF-α is a transforming growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. The biological actions of TGF-α and EGF are similar. For instance, TGF-α and EGF bind to the same receptor. When TGF-α binds to EGFR it can initiate multiple cell proliferation events.

Transforming growth factor beta 1 (TGFβ1) is the prototype of a growing superfamily of peptide growth factors and plays a prominent role in a variety of cellular processes, including cell-cycle progression, cell differentiation, reproductive function, development, motility, adhesion, neuronal growth, bone morphogenesis, wound healing, and immune surveillance. TGF-β1, TGF-β2 and TGF-β3 signal via the same heteromeric receptor complex, consisting of a ligand binding TGF-β receptor type II (TβR-II), and a TGF-β receptor type I (TβR-I). Signal transduction from the receptor to the nucleus is mediated via SMADs. TGF-β expression is found in cartilage, bone, teeth, muscle, heart, blood vessels, hematopoietic cells, lung, kidney, gut, liver, eye, ear, skin, and the nervous system.

Transforming growth factor beta-2 (TGF-β2) is a secreted protein which belongs to the TGF-beta family. It is known as a cytokine that performs many cellular functions and has a vital role during embryonic development. The precursor is cleaved into mature TGF-beta-2 and LAP, which remains non-covalently linked to mature TGF-beta-2 rendering it inactive. It is an extracellular glycosylated protein. It is known to suppress the effects of interleukin dependent T-cell tumors. Defects in TGFB2 may be a cause of non-syndromic aortic disease (NSAD).

Transforming growth factor beta 2 (TGF-β2) is a member of TGF-beta superfamily that shares a characteristic cysteine knot structure. Mice with TGF-β2 gene deletion show defects in development of cardiac, lung, craniofacial, limb, spinal column, eye, inner ear and urogenital systems. All TGF-β isoforms signal via the same heteromeric receptor complex, consisting of a ligand binding TGF-β receptor type II (TβR-II), and a TGF-β receptor type I (TβR-I). Signal transduction from the receptor to the nucleus is mediated via SMADs. TGF-β expression is found in cartilage, bone, teeth, muscle, heart, blood vessels, hematopoietic cells, lung, kidney, gut, liver, eye, ear, skin, and the nervous system.

Transforming growth factor beta 3(TGFB3) is a member of a TGF -β superfamily which is defined by their structural and functional similarities. TGFB3 is secreted as a complex with LAP. This latent form of TGFB3 becomes active upon cleavage by plasmin, matrix metalloproteases, thrombospondin -1, and a subset of integrins. It binds with high affinity to TGF- β RII, a type II serine/threonine kinase receptor. TGFB3 is involved in cell differentiation, embryogenesis and development. It is believed to regulate molecules involved in cellular adhesion and extracellular matrix (ECM) formation during the process of palate development. Without TGF-β3, mammals develop a deformity known as a cleft palate.

TGF-β1 (transforming growth factor beta 1) is one of three closely related mammalian members of the large TGF-β1 superfamily that share a characteristic cystine knot structure. TGF-β1, -2 and -3 are highly pleiotropic cytokines that act as cellular switches to regulate processes such as immune function, proliferation and epithelial-mesenchymal transition. Each TGF-β isoform has some non-redundant function; for TGF-β1, mice with targeted deletion show defects in hematopoiesis and endothelial differentiation and died of overwhelming inflammation. TGF-β1 signaling begins with high-affinity binding to a type II ser/thr kinase receptor termed TGF-β RII. This receptor then phosphorylates and activates a second ser/thr kinase receptor, TGF-β RI (also called activin receptor‑like kinase (ALK)-5), or alternatively, ALK-1. This complex phosphorylates and activates Smad proteins that regulate transcription.

TGF-β1 (transforming growth factor beta 1) is one of three closely related mammalian members of the large TGF-β1 superfamily that share a characteristic cystine knot structure. TGF-β1, -2 and -3 are highly pleiotropic cytokines that act as cellular switches to regulate processes such as immune function, proliferation and epithelial-mesenchymal transition. Each TGF-β isoform has some non-redundant function; for TGF-β1, mice with targeted deletion show defects in hematopoiesis and endothelial differentiation and died of overwhelming inflammation. TGF-β1 signaling begins with high-affinity binding to a type II ser/thr kinase receptor termed TGF-β RII. This receptor then phosphorylates and activates a second ser/thr kinase receptor, TGF-β RI (also called activin receptor‑like kinase (ALK)-5), or alternatively, ALK-1. This complex phosphorylates and activates Smad proteins that regulate transcription.

Thermal Printer Paper, 80 mm wide x 47 mm diameter x 82 ft long

Thermo Scientific HyperSep C18 SPE Cartridges, 75 mL, 10 g

Thermo Scientific Nalgene 10 mL Oak Ridge Centrifuge Tube, FEP

Thermo Scientific Nalgene 10 mL Oak Ridge High-Speed Polycarbonate Centrifuge Tubes with 13 mm Linerless Polypropylene Closure

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Thermo Scientific Nalgene 12 mL Round Polycarbonate Centrifuge Tubes

Thermo Scientific Nalgene 12 mL Round Polycarbonate Centrifuge Tubes

Thermo Scientific Nalgene 15 ml Round Bottom Smooth walled Centrifuge Tube, PPCO

Thermo Scientific Nalgene 15 ml Round Bottom Smooth walled Centrifuge Tube, PPCO

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Thermo Scientific Nalgene 16 mL Oak Ridge High-Speed PPCO Centrifuge Tubes with 15 mm PP Sealing Caps with Silicone Gaskets

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Thermo Scientific Nalgene 16 mL Round Bottom Smooth walled Centrifuge Tube, PPCO

Thermo Scientific Nalgene 16 mL Round Polycarbonate Centrifuge Tubes

Thermo Scientific Nalgene 16 mL Round Polycarbonate Centrifuge Tubes

Thermo Scientific Nalgene 30 mL Oak Ridge Centrifuge Tube, FEP

Thermo Scientific Nalgene 30 mL Oak Ridge High-Speed Polycarbonate Centrifuge Tubes with 20 mm Linerless Polypropylene Closure

Thermo Scientific Nalgene 30 mL Oak Ridge High-Speed Polycarbonate Centrifuge Tubes with 20 mm Linerless Polypropylene Closure

Thermo Scientific Nalgene 30 mL Oak Ridge High-Speed PPCO Centrifuge Tubes with 20 mm Linerless Polypropylene Closures

Thermo Scientific Nalgene 30 mL Oak Ridge High-Speed PPCO Centrifuge Tubes with 20 mm PolypropyleneSealing Caps with Silicone Gaskets

Thermo Scientific Nalgene 30 mL Oak Ridge High-Speed PPCO Centrifuge Tubes with 20 mm PolypropyleneSealing Caps with Silicone Gaskets

Thermo Scientific Nalgene 30 mL Oak Ridge Polysulfone Centrifuge Tubes with Screw Caps

Thermo Scientific Nalgene 30 mL Oak Ridge Polysulfone Centrifuge Tubes with Screw Caps

Thermo Scientific Nalgene 38 mL Round Bottom Smooth Walled Centrifuge Tube, PPCO

Thermo Scientific Nalgene 38 mL Round Bottom Smooth Walled Centrifuge Tube, PPCO

Thermo Scientific Nalgene 38 mL Round Polycarbonate Centrifuge Tubes

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Thermo Scientific Nalgene 50 mL Oak Ridge Centrifuge Tube, FEP

Thermo Scientific Nalgene 50 mL Oak Ridge High-Speed Polycarbonate Centrifuge Tubes with 24 mm Linerless Polypropylene Closure

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Thermo Scientific Nalgene 50 mL Oak Ridge High-Speed PPCO Centrifuge Tubes with 24 mm Linerless PP Closures

Thermo Scientific Nalgene 50 mL Oak Ridge High-Speed PPCO Centrifuge Tubes with 24 mm Linerless PP Closures